Stereotactic neurosurgery as a symptomatic treatment for autism spectrum disorders: A systematic review

被引:2
作者
Wu, Yang [1 ]
Meng, Ya-jing [2 ]
Shi, Yi-feng [1 ]
Li, Jia-ming [1 ]
Xu, Yang-yang [1 ]
Zhang, Shu-xin [3 ]
Tian, Rui [1 ]
He, Jiao-jiang [1 ]
Ding, Yi [4 ]
Wang, Wei [1 ,5 ]
机构
[1] Sichuan Univ, West China Hosp, Dept Neurosurg, 37 Guoxue Alley, Chengdu, Sichuan, Peoples R China
[2] Sichuan Univ, West China Hosp, Mental Hlth Ctr, Chengdu, Sichuan, Peoples R China
[3] Sichuan Univ, West China Coll Basic Med & Forens Med, Dept Histoembryol & Neurobiol, Chengdu, Sichuan, Peoples R China
[4] Univ Elect Sci & Technol, Chengdu, Sichuan, Peoples R China
[5] Sichuan Univ, West China Hosp, Dept Neurosurg, 37 Guoxue Alley, Chengdu 610000, Sichuan, Peoples R China
关键词
Autism spectrum disorders; Stereotactic neurosurgery; Deep brain stimulation (DBS); Safety; Efficacy; DEEP BRAIN-STIMULATION; OBSESSIVE-COMPULSIVE DISORDER; ANTERIOR CINGULOTOMY; AMYGDALOTOMY; BEHAVIOR; EPILEPSY; CHILDREN; PATIENT;
D O I
10.1016/j.ajp.2023.103541
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Stereotactic neurosurgery has been employed in autism spectrum disorders (ASD). However, its safety and effectiveness remain unclear owing to limited sample size and other methodological limitations. We aimed to systematically investigate the safety and efficacy of stereotactic neurosurgery for ASD. Eleven studies with 36 patients were included. Stereotactic neurosurgery alleviated the obsessive-compulsive disorder and aggressive behavior symptoms in ASD, with a mean improvement of 42.74% and 59.59% in the Yale-Brown Obsessive Compulsive Scale and Overt Aggression Scale scores, respectively. Systematic studies are necessary to explore the role of deep brain stimulation for social and communication difficulties in ASD.
引用
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页数:9
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