Methods for calculating ventilation rates during resuscitation from out-of-hospital cardiac arrest

Objective: Ventilation control is important during resuscitation from out-of-hospital cardiac arrest (OHCA). We compared different methods for cal-culating ventilation rates (VR) during OHCA. Methods: We analyzed data from the Pragmatic Airway Resuscitation Trial, identifying ventilations through capnogram recordings. We determined VR by: 1) counting the number of breaths within a time epoch ("counted" VR), and 2) calculating the mean of the inverse of measured time between breaths within a time epoch ("measured" VR). We repeated the VR estimates using different time epochs (10, 20, 30, 60 sec). We defined hypo-and hyperventilation as VR <6 and >12 breaths/min, respectively. We assessed differences in estimated hypo-and hyperventilation with each VR mea-surement technique. Results: Of 3,004 patients, data were available for 1,010. With the counted method, total hypoventilation increased with longer time epochs ([10-s epoch: 75 sec hypoventilation] to [60-s epoch: 97 sec hypoventilation]). However, with the measured method, total hypoventilation decreased with longer time epochs ([10-s epoch: 223 sec hypoventilation] to [60-s epoch: 150 sec hypoventilation]). With the counted method, the total duration of hyperventilation decreased with longer time epochs ([10-s epochs: 35 sec hyperventilation] to [60-s epoch: 0 sec hyperventilation]). With the mea-sured method, total hyperventilation decreased with longer time epochs ([10-s epoch: 78 sec hyperventilation] to [60-s epoch: 0 sec hyperventila-tion]). Differences between the measured and counted estimates were smallest with a 60-s time epoch. Conclusions: Quantifications of hypo-and hyperventilation vary with the applied measurement methods. Measurement methods are important when characterizing ventilation rates in OHCA.