Extracellular vesicles of immune cells; immunomodulatory impacts and therapeutic potentials

被引：16

作者：

Mahmoudi, Fariba ^{[1
]}

Hanachi, Parichehr ^{[1
]}

Montaseri, Azadeh ^{[2
]}

机构：

[1] Alzahra Univ, Fac Biol Sci, Dept Biotechnol, Tehran, Iran

[2] Sapienza Univ Rome, Dept Anat Histol Forens Med & Orthopaed, Unit Histol & Med Embryol, I-00161 Rome, Italy

来源：

CLINICAL IMMUNOLOGY | 2023年 / 248卷

关键词：

Extracellular vesicles (EVs); Immune cells; Autoimmune disorders; Exosome; Immunomodulating effects; MACROPHAGE-DERIVED EXOSOMES; DENDRITIC CELLS; T-CELLS; ANTIGEN PRESENTATION; NK CELLS; IN-VITRO; INFLAMMATION; ACTIVATE; DISEASE; MICROPARTICLES;

D O I：

10.1016/j.clim.2023.109237

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Extracellular vesicles (EVs) are a diverse collection of lipid bilayer-membrane-bound particles which are released from cells into the extracellular space and biologic fluids. In multicellular organisms, these vesicles facilitate the exchange of bioactive compounds such as RNA, DNA, proteins, various metabolites, and lipids between the cells. EVs are produced and released by almost all eukaryotic cells including immune cells and can have immuno-modulating effects by either stimulation or suppression of their activities. This immune-modulating feature may provide a promising strategy for treating immune-mediated diseases such as cancer, neurodegenerative diseases, autoimmune disorders and graft-versus-host disease. Moreover, immune cell-derived EVs have received attention as potential biomarkers for being used as diagnostic tools and preventive strategies such as for developing vaccines. In this review, we focus on the EVs produced by different immune cell types, their effects on the immune system, and highlight their potential applications for immunotherapy.

引用

页数：9

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