Ozonized Hydrogels vs. 1% Chlorhexidine Gel for the Clinical and Domiciliary Management of Peri-Implant Mucositis: A Randomized Clinical Trial

被引:11
作者
Butera, Andrea [1 ,2 ]
Pascadopoli, Maurizio [3 ]
Gallo, Simone [3 ]
Martinez, Carlos Perez-Albacete [4 ]
de Val, Jose Eduardo Mate Sanchez [4 ]
Parisi, Luca [5 ]
Gariboldi, Alice [1 ]
Scribante, Andrea [1 ,3 ]
机构
[1] Univ Pavia, Dept Clin Surg Diagnost & Pediat Sci, Unit Dent Hyg, Sect Dent, I-27100 Pavia, Italy
[2] Univ Catol Murcia UCAM, Hlth Sci PhD Programme, Campus Ios Jeronimos N 135, Guadalupe 30107, Murcia, Spain
[3] Univ Pavia, Dept Clin Surg Diagnost & Pediat Sci, Unit Orthodont & Pediat Dent, Sect Dent, I-27100 Pavia, Italy
[4] UCAM Univ Catolica San Antonio Murcia, Fac Hlth Sci, Tissue Regenerat & Repair Grp, Biomat & Tissue Engn, Murcia 30107, Spain
[5] Univ Milan, Dept Biomed Surg & Dent Sci, I-20122 Milan, Italy
关键词
ozone; ozonated oils; peri-implant mucositis; chlorhexidine; scaling and root planing; implants; periodontal parameters; randomized clinical trial; CONSENSUS REPORT; OZONE THERAPY; PERIODONTITIS; DISEASES;
D O I
10.3390/jcm12041464
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Peri-implant mucositis consists of a reversible inflammation of peri-implant tissues characterized by bleeding on gentle probing in the absence of bone loss. Ozone therapy is being extensively studied for its efficacy in treating different dental conditions. To date, few studies have evaluated ozone as an adjunct to the oral hygiene measures of peri-implant mucositis patients. The aim of the present study is to assess the efficacy of an ozonized gel (Trial group) compared to chlorhexidine (Control group) after a domiciliary protocol of oral hygiene in a 6-month study. According to a split-mouth study design, patients were divided into Group 1 for the application of chlorhexidine gel in peri-implant mucositis sites of quadrants Q1 and Q3, whereas in quadrants Q2 and Q4, the ozonized gel was in-office administered. For Group 2, the quadrants were inverted. At baseline (T0), and after 1 (T1), 2 (T2), and 3 (T3) months, Probing Depth (PD), Plaque Index (PI), SI Suppuration Index (SI), Bleeding Score (BS) and Marginal Mucosa Condition (MMC) were measured. A statistically significant decrease was found for all the variables assessed in each group (p < 0.05), whereas significant intergroup differences were found only for PI, BoP, and BS. Accordingly, both agents tested in this study showed an efficacy in treating peri-implant mucositis. The ozonized gel deserves particular attention, considering the better outcome than chlorhexidine on specific clinical periodontal parameters, as well as its lesser shortcomings.
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页数:11
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