A three-gene leukaemic stem cell signature score is robustly prognostic in chronic myelomonocytic leukaemia

被引：1

作者：

Wang, Yu-Hung ^{[1
,2
]}

Yao, Chi-Yuan ^{[2
,4
]}

Lin, Chien-Chin ^{[2
]}

Gurashi, Kristian ^{[1
]}

Amaral, Fabio M. R. ^{[3
]}

Bossenbroek, Hasse ^{[1
]}

Jerez, Andres ^{[5
]}

Somervaille, Tim C. P. ^{[3
]}

Binder, Moritz ^{[6
]}

Patnaik, Mrinal M. ^{[6
]}

Hou, Hsin-An ^{[2
]}

Chou, Wen-Chien ^{[2
]}

Batta, Kiran ^{[1
]}

Wiseman, Daniel H. ^{[1
,8
]}

Tien, Hwei-Fang ^{[2
,7
,9
]}

机构：

[1] Univ Manchester, Div Canc Sci, Manchester, England

[2] Natl Taiwan Univ Hosp, Div Hematol, Taipei, Taiwan

[3] Canc Res UK Manchester Inst, Leukaemia Biol Lab, Manchester, England

[4] Natl Taiwan Univ Hosp, Dept Lab Med, Taipei, Taiwan

[5] Hosp Morales Meseguer, Haematol Dept, Murcia, Spain

[6] Mayo Clin, Dept Internal Med, Div Hematol, Rochester, MN USA

[7] Fra Eastern Mem Hosp, Dept Internal Med, New Taipei City, Taiwan

[8] Univ Manchester, Div Canc Sci, Oxford Rd, Manchester M13 9PL, England

[9] Natl Taiwan Univ Hosp, Dept Internal Med, 7 Chung Shan S Rd, Taipei City 10002, Taiwan

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2023年 / 201卷 / 02期

关键词：

chronic myelomonocytic leukaemia; leukaemia stem cell; prognostic scoring system; ACUTE MYELOID-LEUKEMIA; HEMATOPOIETIC STEM; INDEPENDENTLY PREDICT; EXPRESSION; DNMT3B; GENE; MAINTENANCE;

D O I：

10.1111/bjh.18681

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Leukaemic stem cell (LSC) gene expression has recently been linked to prognosis in patients with acute myeloid leukaemia (17-gene LSC score, LSC-17) and myelodysplastic syndromes. Although chronic myelomonocytic leukaemia (CMML) is regarded as a stem cell disorder, the clinical and biological impact of LSCs on CMML patients remains elusive. Making use of multiple independent validation cohorts, we here describe a concise three-gene expression signature (LSC-3, derived from the LSC-17 score) as an independent and robust prognostic factor for leukaemia-free and overall survival in CMML. We propose that LSC-3 could be used to supplement existing risk stratification systems, to improve prognostic performance and guide management decisions.

引用

页码：302 / 307

页数：6

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