A three-gene leukaemic stem cell signature score is robustly prognostic in chronic myelomonocytic leukaemia

被引：1
|
作者：
Wang, Yu-Hung [1 ,2 ]
Yao, Chi-Yuan [2 ,4 ]
Lin, Chien-Chin [2 ]
Gurashi, Kristian [1 ]
Amaral, Fabio M. R. [3 ]
Bossenbroek, Hasse [1 ]
Jerez, Andres [5 ]
Somervaille, Tim C. P. [3 ]
Binder, Moritz [6 ]
Patnaik, Mrinal M. [6 ]
Hou, Hsin-An [2 ]
Chou, Wen-Chien [2 ]
Batta, Kiran [1 ]
Wiseman, Daniel H. [1 ,8 ]
Tien, Hwei-Fang [2 ,7 ,9 ]
机构：
[1] Univ Manchester, Div Canc Sci, Manchester, England
[2] Natl Taiwan Univ Hosp, Div Hematol, Taipei, Taiwan
[3] Canc Res UK Manchester Inst, Leukaemia Biol Lab, Manchester, England
[4] Natl Taiwan Univ Hosp, Dept Lab Med, Taipei, Taiwan
[5] Hosp Morales Meseguer, Haematol Dept, Murcia, Spain
[6] Mayo Clin, Dept Internal Med, Div Hematol, Rochester, MN USA
[7] Fra Eastern Mem Hosp, Dept Internal Med, New Taipei City, Taiwan
[8] Univ Manchester, Div Canc Sci, Oxford Rd, Manchester M13 9PL, England
[9] Natl Taiwan Univ Hosp, Dept Internal Med, 7 Chung Shan S Rd, Taipei City 10002, Taiwan
来源：
BRITISH JOURNAL OF HAEMATOLOGY | 2023年 / 201卷 / 02期
关键词：
chronic myelomonocytic leukaemia; leukaemia stem cell; prognostic scoring system; ACUTE MYELOID-LEUKEMIA; HEMATOPOIETIC STEM; INDEPENDENTLY PREDICT; EXPRESSION; DNMT3B; GENE; MAINTENANCE;
D O I：
10.1111/bjh.18681
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Leukaemic stem cell (LSC) gene expression has recently been linked to prognosis in patients with acute myeloid leukaemia (17-gene LSC score, LSC-17) and myelodysplastic syndromes. Although chronic myelomonocytic leukaemia (CMML) is regarded as a stem cell disorder, the clinical and biological impact of LSCs on CMML patients remains elusive. Making use of multiple independent validation cohorts, we here describe a concise three-gene expression signature (LSC-3, derived from the LSC-17 score) as an independent and robust prognostic factor for leukaemia-free and overall survival in CMML. We propose that LSC-3 could be used to supplement existing risk stratification systems, to improve prognostic performance and guide management decisions.
引用
收藏
页码：302 / 307
页数：6
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