Red/processed meat consumption and non-cancer-related outcomes in humans: umbrella review

The associations of red/processed meat consumption and cancer-related health outcomes have been well discussed. The umbrella review aimed to summarise the associations of red/processed meat consumption and various non-cancer-related outcomes in humans. We systematically searched the systematic reviews and meta-analyses of associations between red/processed meat intake and health outcomes from PubMed, Embase, Web of Science and the Cochrane Library databases. The umbrella review has been registered in PROSPERO (CRD 42021218568). A total of 40 meta-analyses were included. High consumption of red meat, particularly processed meat, was associated with a higher risk of all-cause mortality, CVD and metabolic outcomes. Dose-response analysis revealed that an additional 100 g/d red meat intake was positively associated with a 17 % increased risk of type 2 diabetes mellitus (T2DM), 15 % increased risk of CHD, 14 % of hypertension and 12 % of stroke. The highest dose-response/50 g increase in processed meat consumption at 95 % confident levels was 1 center dot 37, 95 % CI (1 center dot 22, 1 center dot 55) for T2DM, 1 center dot 27, 95 % CI (1 center dot 09, 1 center dot 49) for CHD, 1 center dot 17, 95 % CI (1 center dot 02, 1 center dot 34) for stroke, 1 center dot 15, 95 % CI (1 center dot 11, 1 center dot 19) for all-cause mortality and 1 center dot 08, 95 % CI (1 center dot 02, 1 center dot 14) for heart failure. In addition, red/processed meat intake was associated with several other health-related outcomes. Red and processed meat consumption seems to be more harmful than beneficial to human health in this umbrella review. It is necessary to take the impacts of red/processed meat consumption on non-cancer-related outcomes into consideration when developing new dietary guidelines, which will be of great public health importance. However, more additional randomised controlled trials are warranted to clarify the causality.