Antiviral Activity of Technologically Processed Antibodies to CD4 Receptor against Influenza Infection

被引：0
|
作者：
Petrova, N. V. [1 ,3 ]
Emelyanova, A. G. [1 ,3 ]
Tarasov, S. A. [1 ,3 ]
Glubokova, E. A. [2 ]
Kartashova, N. P. [2 ]
机构：
[1] Res Inst Gen Pathol & Pathophysiol, Moscow, Russia
[2] II Mechnikov Res Inst Vaccines & Sera, Moscow, Russia
[3] LLC MATERIA MEDICA HOLDING, Moscow, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2022年 / 174卷 / 02期
关键词：
influenza A infection; technologically processed antibodies; CD4; receptor; Ergoferon; Raphamin; EFFICACY; OSELTAMIVIR; ERGOFERON; SAFETY;
D O I：
10.1007/s10517-023-05683-8
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The antiviral activity of technologically processed antibodies to CD4 receptor was evaluated a model of sublethal A/California/04/2009 (H1N1)pdm09-induced influenza infection in female BALB/c mice. The technologically processed antibodies increased animal survival rate by 50% in comparison with the placebo group (p < 0.05), which correlated with significant inhibition of virus replication in the lungs (p < 0.05). The reference drug Tamiflu increased mouse survival rate (by 47%), decreased the virus titer in the lungs, and prevented body weight loss (p < 0.05 in comparison with the placebo group by all parameters). The intrinsic protective activity of technologically processed antibodies to CD4 receptor was demonstrated, which manifested in a decrease in viral load in the lower respiratory tract and an increase in the survival rate.
引用
收藏
页码：250 / 253
页数：4
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