Antiviral Activity of Technologically Processed Antibodies to CD4 Receptor against Influenza Infection

被引：0

作者：

Petrova, N. V. ^{[1
,3
]}

Emelyanova, A. G. ^{[1
,3
]}

Tarasov, S. A. ^{[1
,3
]}

Glubokova, E. A. ^{[2
]}

Kartashova, N. P. ^{[2
]}

机构：

[1] Res Inst Gen Pathol & Pathophysiol, Moscow, Russia

[2] II Mechnikov Res Inst Vaccines & Sera, Moscow, Russia

[3] LLC MATERIA MEDICA HOLDING, Moscow, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2022年 / 174卷 / 02期

关键词：

influenza A infection; technologically processed antibodies; CD4; receptor; Ergoferon; Raphamin; EFFICACY; OSELTAMIVIR; ERGOFERON; SAFETY;

D O I：

10.1007/s10517-023-05683-8

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The antiviral activity of technologically processed antibodies to CD4 receptor was evaluated a model of sublethal A/California/04/2009 (H1N1)pdm09-induced influenza infection in female BALB/c mice. The technologically processed antibodies increased animal survival rate by 50% in comparison with the placebo group (p < 0.05), which correlated with significant inhibition of virus replication in the lungs (p < 0.05). The reference drug Tamiflu increased mouse survival rate (by 47%), decreased the virus titer in the lungs, and prevented body weight loss (p < 0.05 in comparison with the placebo group by all parameters). The intrinsic protective activity of technologically processed antibodies to CD4 receptor was demonstrated, which manifested in a decrease in viral load in the lower respiratory tract and an increase in the survival rate.

引用

页码：250 / 253

页数：4

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