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Molecular mechanisms of resveratrol and its silver nanoparticle conjugate in addressing sepsis-induced lung injury
被引:5
作者:
Ustundag, Hilal
[1
]
Kara, Adem
[2
]
Doganay, Songul
[3
]
Kurt, Nezahat
[4
]
Erbas, Elif
[5
]
Kalindemirtas, Ferdane Danisman
[1
]
Kariper, Ishak Afsin
[6
]
机构:
[1] Erzincan Binali Yildirim Univ, Fac Med, Dept Physiol, TR-2400 Erzincan, Turkiye
[2] Erzurum Tech Univ, Fac Sci, Dept Mol Biol & Genet, Erzurum, Turkiye
[3] Sakarya Univ, Fac Med, Dept Physiol, Sakarya, Turkiye
[4] Erzincan Binali Yildirim Univ, Fac Med, Dept Biochem, Erzincan, Turkiye
[5] Fac Vet Med, Dept Vet Histol & Embryol, Vet Med Basic Sci, Erzurum, Turkiye
[6] Erciyes Univ, Educ Fac, Dept Sci Educ, Kayseri, Turkiye
关键词:
Polymicrobial sepsis;
Resveratrol;
Silver nanoparticles;
Oxidative stress;
Inflammatory response;
P2X7;
RECEPTOR;
INNATE IMMUNITY;
SEPTIC SHOCK;
RELEASE;
TOLL-LIKE-RECEPTOR-4;
P2X(7);
D O I:
10.1007/s00210-024-03058-y
中图分类号:
R9 [药学];
学科分类号:
1007 ;
摘要:
Sepsis is a life-threatening condition characterized by a systemic inflammatory response to infection. Despite extensive research on its pathophysiology, effective therapeutic approaches remain a challenge. This study investigated the potential of resveratrol (RV) and silver nanoparticle-enhanced resveratrol (AgNP-RV) as treatments for sepsis-induced lung injury using a rat model of polymicrobial sepsis induced by cecal ligation and puncture (CLP). The study focused on evaluating changes in oxidative status (TAS, TOS, and OSI) and the expression of inflammatory and apoptotic markers (IL-1 beta, TNF-alpha, P2X7R, TLR4, Caspase-3, and Bcl-2) in lung tissue. Both RV and AgNP-RV demonstrated potential in mitigating oxidative stress, inflammation, and apoptosis, with AgNP-RV exhibiting greater efficacy than RV alone (p < 0.05). These findings were corroborated by histopathological analyses, which revealed reduced tissue damage in the RV- and AgNP-RV-treated groups. Our study highlights the therapeutic potential of RV and, particularly, AgNP-RV in combating sepsis-induced oxidative stress, inflammation, and apoptosis. It also underscores the promise of nanoparticle technology in enhancing therapeutic outcomes. However, further investigations are warranted to fully understand the mechanisms of action, especially concerning the role of the P2X7 receptor in the observed effects. Nonetheless, our research suggests that RV and AgNP-RV hold promise as novel strategies for sepsis management.
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页码:6249 / 6261
页数:13
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