Modulating the acetylation of α-tubulin by LncRNAs and microRNAs helps in the progression of cancer

被引：2

作者：

Kar, Sneha ^{[1
]}

Mukherjee, Rimi ^{[1
]}

Guha, Subhabrata ^{[1
]}

Talukdar, Debojit ^{[1
]}

Das, Gaurav ^{[1
]}

Murmu, Nabendu ^{[1
]}

机构：

[1] Chittaranjan Natl Canc Inst, Dept Signal Transduct & Biogenic Amines, Kolkata, India

来源：

CELL BIOCHEMISTRY AND FUNCTION | 2024年 / 42卷 / 02期

关键词：

alpha-tubulin; acetylation; cancer metastasis; lncRNA; miRNA; DOWN-REGULATION; CELLS PROMOTES; EXPRESSION; FIBROBLASTS; CARCINOMA; MIGRATION; INVASION; HDAC6; PROLIFERATION; CYTOSKELETON;

D O I：

10.1002/cbf.3953

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Malignant tumor cells go through morphological and gene expression alterations, including rearrangement of cytoskeleton proteins that promote invasion and metastasis. Microtubules form a major cytoskeleton component that plays a significant role in regulating multiple cellular activities and function depending on the presence of posttranslational modification (PTM). Acetylation is a type of PTM that generally occurs in the lysine 40 region of alpha-tubulin and is known to be critically associated with cancer metastasis. Current evidence demonstrates that noncoding RNAs, such as long noncoding RNA (lncRNA) and microRNA (or miRNA), which are correlated with gene regulation modulate the expression of acetylated tubulin in the development and metastasis of cancer. This review provides an overview about the role of lncRNA and miRNA in regulation of tubulin acetylation in various types of cancer.

引用

页数：13

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