Pyroptosis: a new insight into intestinal inflammation and cancer

被引：9
|
作者：
Chao, Limin [1 ]
Zhang, Wenjing [1 ]
Feng, Yuchao [1 ]
Gao, Pei [1 ]
Ma, Jinyou [1 ]
机构：
[1] Henan Inst Sci & Technol, Coll Anim Sci & Vet Med, Xinxiang, Peoples R China
来源：
FRONTIERS IN IMMUNOLOGY | 2024年 / 15卷
基金：
中国国家自然科学基金;
关键词：
pyroptosis; inflammasomes; intestinal inflammation; cancer; gut microbiota; intestinal mucosal barrier; NLRP3; INFLAMMASOME; ACTIVATION; COLITIS; CASPASE-1; GUT; TUMORIGENESIS; MACROPHAGES; HOMEOSTASIS; APOPTOSIS; TARGET;
D O I：
10.3389/fimmu.2024.1364911
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Pyroptosis is an innate immune response triggered by the activation of inflammasomes by various influencing factors, characterized by cell destruction. It impacts the immune system and cancer immunotherapy. In recent years, the roles of pyroptosis and inflammasomes in intestinal inflammation and cancer have been continuously confirmed. This article reviews the latest progress in pyroptosis mechanisms, new discoveries of inflammasomes, mutual regulation between inflammasomes, and their applications in intestinal diseases. Additionally, potential synergistic treatment mechanisms of intestinal diseases with pyroptosis are summarized, and challenges and future directions are discussed, providing new ideas for pyroptosis therapy.
引用
收藏
页数：9
相关论文
共 50 条
  • [31] Pyroptosis-based nanotherapeutics: Possible mechanisms for cancer treatment
    Muppala, Veda
    Farran, Batoul
    Nagaraju, Ganji Purnachandra
    LIFE SCIENCES, 2022, 308
  • [32] New prospects of cancer therapy based on pyroptosis and pyroptosis inducers
    Qiaoyun Chen
    Yuxiang Sun
    Siliang Wang
    Jingyan Xu
    Apoptosis, 2024, 29 : 66 - 85
  • [33] Methods for monitoring cancer cell pyroptosis
    Wang, Shuo
    Liu, Yuantong
    Zhang, Lu
    Sun, Zhijun
    CANCER BIOLOGY & MEDICINE, 2022, 19 (04) : 398 - 414
  • [34] Inflammasomes in Intestinal Inflammation and Cancer
    Chen, Grace Y.
    Nunez, Gabriel
    GASTROENTEROLOGY, 2011, 141 (06) : 1986 - 1999
  • [35] Cannabinoids in intestinal inflammation and cancer
    Izzo, Angelo A.
    Camilleri, Michael
    PHARMACOLOGICAL RESEARCH, 2009, 60 (02) : 117 - 125
  • [36] Necrosulfonamide ameliorates intestinal inflammation via inhibiting GSDMD-medicated pyroptosis and MLKL-mediated necroptosis
    Yang, Wenchang
    Tao, Kaixiong
    Wang, Yaxin
    Huang, Yongzhou
    Duan, Caihan
    Wang, Tao
    Li, Chengguo
    Zhang, Peng
    Yin, Yuping
    Gao, Jinbo
    Li, Ruidong
    BIOCHEMICAL PHARMACOLOGY, 2022, 206
  • [37] Pyroptosis and pyroptosis-inducing cancer drugs
    Fan Yang
    Sahana N. Bettadapura
    Mark S. Smeltzer
    Hua Zhu
    Shanzhi Wang
    Acta Pharmacologica Sinica, 2022, 43 : 2462 - 2473
  • [38] Pyroptosis and pyroptosis-inducing cancer drugs
    Yang, Fan
    Bettadapura, Sahana N.
    Smeltzer, Mark S.
    Zhu, Hua
    Wang, Shanzhi
    ACTA PHARMACOLOGICA SINICA, 2022, 43 (10) : 2462 - 2473
  • [39] Mincle/Syk Signalling Promotes Intestinal Mucosal Inflammation Through Induction of Macrophage Pyroptosis in Crohn's Disease
    Gong, Wenbin
    Zheng, Tao
    Kun, Guo
    Miao, Fang
    Xie, Haohao
    Li, Weijie
    Tang, Qinqing
    Hong, Zhiwu
    Ren, Huajian
    Gu, Guosheng
    Wang, Gefei
    Wu, Xiuwen
    Zhao, Yun
    Ren, Jianan
    JOURNAL OF CROHNS & COLITIS, 2020, 14 (12) : 1734 - 1747
  • [40] The combined effect of deoxynivalenol and Fumonisin B1 on small intestinal inflammation mediated by pyroptosis in vivo and in vitro
    Mao, Xinru
    Zhang, Ping
    Du, Heng
    Ge, Lei
    Liu, Shuiping
    Huang, Kehe
    Chen, Xingxiang
    TOXICOLOGY LETTERS, 2023, 372 : 25 - 35
12345