Pyroptosis: a new insight into intestinal inflammation and cancer

被引：11

作者：

Chao, Limin ^{[1
]}

Zhang, Wenjing ^{[1
]}

Feng, Yuchao ^{[1
]}

Gao, Pei ^{[1
]}

Ma, Jinyou ^{[1
]}

机构：

[1] Henan Inst Sci & Technol, Coll Anim Sci & Vet Med, Xinxiang, Peoples R China

来源：

FRONTIERS IN IMMUNOLOGY | 2024年 / 15卷

基金：

中国国家自然科学基金;

关键词：

pyroptosis; inflammasomes; intestinal inflammation; cancer; gut microbiota; intestinal mucosal barrier; NLRP3; INFLAMMASOME; ACTIVATION; COLITIS; CASPASE-1; GUT; TUMORIGENESIS; MACROPHAGES; HOMEOSTASIS; APOPTOSIS; TARGET;

D O I：

10.3389/fimmu.2024.1364911

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Pyroptosis is an innate immune response triggered by the activation of inflammasomes by various influencing factors, characterized by cell destruction. It impacts the immune system and cancer immunotherapy. In recent years, the roles of pyroptosis and inflammasomes in intestinal inflammation and cancer have been continuously confirmed. This article reviews the latest progress in pyroptosis mechanisms, new discoveries of inflammasomes, mutual regulation between inflammasomes, and their applications in intestinal diseases. Additionally, potential synergistic treatment mechanisms of intestinal diseases with pyroptosis are summarized, and challenges and future directions are discussed, providing new ideas for pyroptosis therapy.

引用

页数：9

共 80 条

[11] AIM2 Engages Active but Unprocessed Caspase-1 to Induce Noncanonical Activation of the NLRP3 Inflammasome [J].

Cunha, Larissa D. ;

Silva, Alexandre L. N. ;

Ribeiro, Juliana M. ;

Mascarenhas, Danielle P. A. ;

Quirino, Gustavo F. S. ;

Santos, Leonardo L. ;

Flavell, Richard A. ;

Zamboni, Dario S. .

CELL REPORTS, 2017, 20 (04) :794-805

[12] Targeting Inflammasome Activation in Viral Infection: A Therapeutic Solution? [J].

Deng, Chuan-Han ;

Li, Tian-Qi ;

Zhang, Wei ;

Zhao, Qi ;

Wang, Ying .

VIRUSES-BASEL, 2023, 15 (07)

[13] The roles of inflammasomes in cancer [J].

Deng, Zihan ;

Lu, Lisen ;

Li, Binghui ;

Shi, Xiujuan ;

Jin, Honglin ;

Hu, Weidong .

FRONTIERS IN IMMUNOLOGY, 2023, 14

[14] Control of Intestinal Homeostasis, Colitis, and Colitis-Associated Colorectal Cancer by the Inflammatory Caspases [J].

Dupaul-Chicoine, Jeremy ;

Yeretssian, Garabet ;

Doiron, Karine ;

Bergstrom, Kirk S. B. ;

McIntire, Christian R. ;

LeBlanc, Philippe M. ;

Meunier, Charles ;

Turbide, Claire ;

Gros, Philippe ;

Beauchemin, Nicole ;

Vallance, Bruce A. ;

Saleh, Maya .

IMMUNITY, 2010, 32 (03) :367-378

[15] Focus on the Role of NLRP3 Inflammasome in Diseases [J].

Fusco, Roberta ;

Siracusa, Rosalba ;

Genovese, Tiziana ;

Cuzzocrea, Salvatore ;

Di Paola, Rosanna .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 21 (12) :1-25

[16] Dysregulated Microbiota-Driven Gasdermin D Activation Promotes Colitis Development by Mediating IL-18 Release [J].

Gao, Hanchao ;

Cao, Mengtao ;

Yao, Yikun ;

Hu, Wenjun ;

Sun, Huimin ;

Zhang, Yingwei ;

Zeng, Changchun ;

Tang, Jia ;

Luan, Shaodong ;

Chen, Pengfei .

FRONTIERS IN IMMUNOLOGY, 2021, 12

[17] Mucus: An Underestimated Gut Target for Environmental Pollutants and Food Additives [J].

Gillois, Kevin ;

Leveque, Mathilde ;

Theodorou, Vassilia ;

Robert, Herve ;

Mercier-Bonin, Muriel .

MICROORGANISMS, 2018, 6 (02)

[18] Overexpressed NLRC3 Acts as an Anti-Inflammatory Cytosolic Protein [J].

Gultekin, Yetis ;

Eren, Elif ;

Ozoren, Nesrin .

JOURNAL OF INNATE IMMUNITY, 2015, 7 (01) :25-36

[19] Mucus and mucins in diseases of the intestinal and respiratory tracts [J].

Hansson, G. C. .

JOURNAL OF INTERNAL MEDICINE, 2019, 285 (05) :479-490

[20] The Salmonella invasin SipB induces macrophage apoptosis by binding to caspase-1 [J].

Hersh, D ;

Monack, DM ;

Smith, MR ;

Ghori, N ;

Falkow, S ;

Zychlinsky, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (05) :2396-2401

← 1 2 3 4 5 6 7 8 →