The amide group and its preparation methods by acid-amine coupling reactions: an overview

被引：3
作者：
Agudo-Alvarez, Sandra [1 ]
Diaz-Minguez, Sandra S. [1 ]
Benito-Arenas, Raul [1 ]
机构：
[1] CSIC, Inst Quim Organ Gen, Madrid, Spain
来源：
PURE AND APPLIED CHEMISTRY | 2024年 / 96卷 / 05期
关键词：
Amides; benzotriazole; carbodiimides; guanidinium; uronium; VCCA-2023; PEPTIDE; REAGENTS;
D O I：
10.1515/pac-2023-1104
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The amide bond is one of the most important structural units in nature, as it is part of the backbone of peptides and natural proteins, as well as some essential amino acids, DNA, RNA, hormones, or vitamins found in the body. Furthermore, this bond is significant in the pharmaceutical industry due to its presence in the structure of numerous APIs contained in drugs. This paper reviews the most important methods collected in the bibliography for the preparation of this moiety.
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页码：691 / 707
页数：17
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