One-pot green synthesis of pidotimod in water

被引：0

作者：

Tung, Truong-Thanh ^{[1
,2
]}

Yen, Nguyen T. H. ^{[1
]}

Phuong, Pham B. ^{[1
]}

Huy, Nguyen C. ^{[1
]}

Ngoc, Pham H. ^{[1
]}

Minh, Dinh N. ^{[1
]}

Tung, Pham D. ^{[1
]}

Nam, Nguyen-Hai ^{[3
]}

机构：

[1] PHENIKAA Univ, Fac Pharm, Hanoi 12116, Vietnam

[2] PHENIKAA Univ, PHENIKAA Inst Adv Study PIAS, Hanoi 12116, Vietnam

[3] Hanoi Univ Pharm, Dept Med Chem, Hanoi, Vietnam

来源：

CHEMICAL PAPERS | 2024年 / 78卷 / 05期

关键词：

Pidotimod; Green synthesis; Peptide; Synthesis; Aqueous media; SERS DETECTION; THIRAM; ENHANCEMENT; NANOPARTICLES; NANOSTARS; NANORODS; MXENE;

D O I：

10.1007/s11696-023-03278-1

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Pidotimod is an immunostimulant drug that plays an important role in respiratory diseases. There are several methods for the preparation of pidotimod but require complicated procedures. Herein, we report the one-pot, direct synthesis of the immunostimulant drug pidotimod via the reaction of thiazolidine-4-carboxylic acid and L-pyroglutamic acid in water without the protection step. The reaction runs well at room temperature and simple purification process. We believe that this result could bring a new green method for application in the pharmaceutical industry.

引用

页码：2855 / 2865

页数：11

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