Initial results with [18F]FAPI-74 PET/CT in idiopathic pulmonary fibrosis

被引:9
|
作者
Mori, Yuriko [1 ,2 ]
Kramer, Vasko [3 ,4 ]
Novruzov, Emil [1 ,2 ]
Mamlins, Eduards [1 ,2 ]
Roehrich, Manuel [5 ,6 ]
Fernandez, Rene [3 ]
Amaral, Horacio [3 ,4 ]
Soza-Ried, Cristian [3 ,4 ]
Monje, Barbara [3 ]
Sabbagh, Eduardo [7 ]
Florenzano, Matias [7 ,8 ]
Giesel, Frederik L. [1 ,2 ,9 ]
Undurraga, Alvaro [7 ,10 ]
机构
[1] Heinrich Heine Univ Duesseldorf, Med Fac, Dept Nucl Med, Moorenstrasse 5, D-40225 Dusseldorf, Germany
[2] Heinrich Heine Univ Duesseldorf, Univ Hosp Duesseldorf, Moorenstr 5, D-40225 Dusseldorf, Germany
[3] Positronmed, Ctr Nucl Med & PET CT, Providencia 7501068, Chile
[4] Positronpharma SA, Santiago 7500921, Chile
[5] Heidelberg Univ Hosp, Dept Nucl Med, INF 400, D-69120 Heidelberg, Germany
[6] Mainz Univ Hosp, Dept Nucl Med, Langenbeckstr 1, D-55131 Mainz, Germany
[7] Inst Nacl Torax, Santiago, Chile
[8] Clin Univ los Andes, Santiago, Chile
[9] Osaka Univ, Inst Radiat Sci, Osaka, Japan
[10] Univ Chile, Santiago, Chile
关键词
Fibroblast activation protein; FAPI; PET; Idiopathic pulmonary disease; Fibrosis; ADVANCED OVARIAN-CANCER; PERITONEAL METASTASES; DIAGNOSTIC-ACCURACY; PRIMARY SURGERY; CT; CHEMOTHERAPY; TOMOGRAPHY; MRI;
D O I
10.1007/s00259-023-06564-y
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Idiopathic pulmonary fibrosis (IPF) is a chronic fibrosing interstitial lung disease with a poor prognosis. Ga-68-labeled FAP ligands exhibited highly promising results due to the crucial role of activated fibroblasts in fibrosis imaging of the lung. However, F-18-labeled FAP ligands might provide qualitatively much higher imaging results with accompanying economic benefits due to large-scale production. Thus, we sought to investigate the potential of [F-18]FAPI-74 prospectively in a small patient cohort.Methods: Eight patients underwent both [F-18]FAPI-74-PET/CT and HRCT scans and were then compared with a control group without any fibrosing pulmonary disease. The tracer uptake of fibrotic lung areas was analyzed in synopsis with radiological and clinical parameters.Results: We observed a positive correlation between the fibrotic active volume, the Hounsfield scale, as well as the vital and diffusing capacity of the lung.Conclusion: The initial results confirm our assumption that [F-18]FAPI-74 offers a viable non-invasive assessment method for pulmonary fibrotic changes in patients with IPF.
引用
收藏
页码:1605 / 1611
页数:7
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