Cytotoxic Activity of A-Modified Licorice Triterpenoid Derivatives

被引：1

作者：

Baltina, L. A. ^{[1
]}

Khusnutdinova, N. S. ^{[2
]}

Karimova, E. R. ^{[1
]}

Saifullina, D. R. ^{[2
]}

Kondratenko, R. M. ^{[2
]}

机构：

[1] Russian Acad Sci, Ufa Inst Chem, Ufa Fed Res Ctr, 71 Prosp Oktyabrya, Ufa 450054, Russia

[2] Bashkir State Med Univ, Minist Hlth Russia, 3 Lenina St, Ufa 450000, Russia

来源：

PHARMACEUTICAL CHEMISTRY JOURNAL | 2023年 / 57卷 / 05期

关键词：

triterpenoids; glycyrrhetic acid; cytotoxicity; GLYCYRRHETINIC ACID; ANTICANCER; GROWTH;

D O I：

10.1007/s11094-023-02931-z

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The cytotoxic activity of a number of A-modified derivatives of glycyrrhetic acid (GLA) and 11-deoxo- and 18,19-dehydro-GLA against conditionally normal HEK 293 cells, A549 human lung carcinoma, MCF-7 breast adenocarcinoma, and SH-SY5Y neuroblastoma cells was studied. The most active compound was 18,19-dehydro-GLA methyl ester with a pyrazole fragment, which exhibited a pronounced cytotoxic effect against A549, MCF-7, and SH-SY5Y cancer cell lines (IC50 22.57 - 38.11 & mu;M).

引用

页码：637 / 641

页数：5

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