Gut Microbiota Composition and Cardiovascular Disease: A Potential New Therapeutic Target?

被引：20

作者：

Belli, Martina ^{[1
,2
]}

Barone, Lucy ^{[1
]}

Longo, Susanna ^{[3
]}

Prandi, Francesca Romana ^{[1
,4
]}

Lecis, Dalgisio ^{[1
]}

Mollace, Rocco ^{[3
,5
]}

Margonato, Davide ^{[2
]}

Muscoli, Saverio ^{[1
]}

Sergi, Domenico ^{[1
]}

Federici, Massimo ^{[3
]}

Barilla, Francesco ^{[1
]}

机构：

[1] Tor Vergata Univ, Dept Syst Med, Div Cardiol, I-00133 Rome, Italy

[2] Ist Sci San Raffaele, Cardiovasc Imaging Unit, I-20132 Milan, Italy

[3] Tor Vergata Univ, Dept Syst Med, I-00133 Rome, Italy

[4] Icahn Sch Med Mt Sinai, Mt Sinai Hosp, Div Cardiol, 1 Gustave L Levy Pl, New York, NY 10029 USA

[5] Humanitas Gavazzeni, Cardiovasc Dept, I-24125 Bergamo, Italy

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 15期

关键词：

gut microbiota; cardiovascular diseases; trimethylamine N-Oxide; heart failure; atherosclerosis; TRIMETHYLAMINE-N-OXIDE; CHRONIC HEART-FAILURE; CLOSTRIDIUM-DIFFICILE INFECTION; INTESTINAL MICROBIOTA; MYOCARDIAL-INFARCTION; RISK; INFLAMMATION; HEALTH; EPIDEMIOLOGY; HYPERTENSION;

D O I：

10.3390/ijms241511971

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A great deal of evidence has revealed an important link between gut microbiota and the heart. In particular, the gut microbiota plays a key role in the onset of cardiovascular (CV) disease, including heart failure (HF). In HF, splanchnic hypoperfusion causes intestinal ischemia resulting in the translocation of bacteria and their metabolites into the blood circulation. Among these metabolites, the most important is Trimethylamine N-Oxide (TMAO), which is responsible, through various mechanisms, for pathological processes in different organs and tissues. In this review, we summarise the complex interaction between gut microbiota and CV disease, particularly with respect to HF, and the possible strategies for influencing its composition and function. Finally, we highlight the potential role of TMAO as a novel prognostic marker and a new therapeutic target for HF.

引用

页数：13

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