Overcoming the Challenges of Phytochemicals in Triple Negative Breast Cancer Therapy: The Path Forward

被引：7

作者：

Alaouna, Mohammed ^{[1
,2
]}

Penny, Clement ^{[2
]}

Hull, Rodney ^{[1
]}

Molefi, Thulo ^{[1
,3
,4
]}

Chauke-Malinga, Nkhensani ^{[1
,5
]}

Khanyile, Richard ^{[1
,3
,4
]}

Makgoka, Malose ^{[1
,6
]}

Bida, Meshack ^{[1
,7
]}

Dlamini, Zodwa ^{[1
]}

机构：

[1] Univ Pretoria, Pan African Canc Res Inst PACRI, DSI NRF SARChI Chair Precis Oncol & Canc Prevent P, SAMRC Precis Oncol Res Unit PORU, ZA-0001 Pretoria, South Africa

[2] Univ Witwatersrand, Fac Hlth Sci, Sch Clin Med, Dept Internal Med, ZA-2193 Parktown, South Africa

[3] Steve Biko Acad Hosp, Dept Med Oncol, ZA-0001 Pretoria, South Africa

[4] Univ Pretoria, ZA-0001 Pretoria, South Africa

[5] Univ Pretoria, Steve Biko Acad Hosp, Fac Hlth Sci, Dept Plast & Reconstruct Surg, ZA-0001 Pretoria, South Africa

[6] Univ Pretoria, Steve Biko Acad Hosp, Fac Hlth Sci, Dept Surg, ZA-0001 Pretoria, South Africa

[7] Univ Pretoria, Dept Anat Pathol, Natl Hlth Lab Serv NHLS, ZA-0001 Pretoria, South Africa

来源：

PLANTS-BASEL | 2023年 / 12卷 / 12期

基金：

新加坡国家研究基金会; 英国医学研究理事会;

关键词：

phytomedicine; tyrosine kinase; Wnt; epithelial to mesenchymal transition; angiogenesis; metastasis; apoptosis; NF-KAPPA-B; SIGNALING PATHWAY; STEM-CELLS; RAS/RAF/MEK/ERK PATHWAY; MESENCHYMAL TRANSITION; RECEPTOR FAMILY; BRCA1; MUTATION; TUMOR INVASION; BETA-CATENIN; APOPTOSIS;

D O I：

10.3390/plants12122350

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Triple negative breast cancer (TNBC) is a very aggressive subtype of breast cancer that lacks estrogen, progesterone, and HER2 receptor expression. TNBC is thought to be produced by Wnt, Notch, TGF-beta, and VEGF pathway activation, which leads to cell invasion and metastasis. To address this, the use of phytochemicals as a therapeutic option for TNBC has been researched. Plants contain natural compounds known as phytochemicals. Curcumin, resveratrol, and EGCG are phytochemicals that have been found to inhibit the pathways that cause TNBC, but their limited bioavailability and lack of clinical evidence for their use as single therapies pose challenges to the use of these phytochemical therapies. More research is required to better understand the role of phytochemicals in TNBC therapy, or to advance the development of more effective delivery mechanisms for these phytochemicals to the site where they are required. This review will discuss the promise shown by phytochemicals as a treatment option for TNBC.

引用

页数：20

共 174 条

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