New Schiff Bases with Thiophene Ring: Synthesis, Biological Activities, and Molecular Docking Study

被引：6
作者：
Celik, F. [1 ]
Bektas, K. I. [2 ]
Guler, H. I. [2 ]
Direkel, S. [3 ]
Unver, Y. [1 ]
机构：
[1] Karadeniz Tech Univ, Fac Sci, Dept Chem, TR-61080 Trabzon, Turkiye
[2] Karadeniz Tech Univ, Fac Sci, Dept Mol Biol & Genet, TR-61080 Trabzon, Turkiye
[3] Giresun Univ, Fac Med, Dept Med Microbiol, TR-28100 Giresun, Turkiye
来源：
RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2023年 / 93卷 / 02期
关键词：
Schiff bases; thiophene; leishmanicidal activity; antimicrobial activity; molecular docking study; DERIVATIVES; ANTIOXIDANT; DFT;
D O I：
10.1134/S107036322302024X
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
In this study, the synthesis of Schiff bases containing substituted thiophene was carried out. The compounds were characterized by Fourier transform infrared (FTIR), H-1 and C-13 NMR spectroscopy methods. In the study, it was aimed to determine in vitro leishmanicidal activities of five different newly synthesized compounds against standard L. infantum promastigotes by microdilution method. In silico analysis was used to examine the probable interactions between the synthesized compound and the target proteins.
引用
收藏
页码：409 / 417
页数：9
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