Nanoparticle drug delivery systems for synergistic delivery of tumor therapy

被引:74
作者
Chen, Daoyuan [1 ]
Liu, Xuecun [2 ]
Lu, Xiaoyan [1 ]
Tian, Jingwei [1 ]
机构
[1] Yantai Univ, Biotech Drugs Univ Shandong, Collaborat Innovat Ctr Adv Drug Delivery Syst & Bi, Sch Pharm,Key Lab Mol Pharmacol & Drug Evaluat,Min, Yantai, Peoples R China
[2] Shandong Boan Biotechnol Co Ltd, Yantai, Peoples R China
关键词
nanoparticles; co-delivery; synergistic action; tumor therapy; combination therapy; MESOPOROUS SILICA NANOPARTICLES; SOLID LIPID NANOPARTICLES; CALCIUM-CARBONATE NANOPARTICLES; TARGETED CO-DELIVERY; ANTITUMOR-ACTIVITY; ANTICANCER DRUGS; HYALURONIC-ACID; CANCER-THERAPY; IN-VITRO; MAGNETIC NANOPARTICLES;
D O I
10.3389/fphar.2023.1111991
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Nanoparticle drug delivery systems have proved anti-tumor effects; however, they are not widely used in tumor therapy due to insufficient ability to target specific sites, multidrug resistance to anti-tumor drugs, and the high toxicity of the drugs. With the development of RNAi technology, nucleic acids have been delivered to target sites to replace or correct defective genes or knock down specific genes. Also, synergistic therapeutic effects can be achieved for combined drug delivery, which is more effective for overcoming multidrug resistance of cancer cells. These combination therapies achieve better therapeutic effects than delivering nucleic acids or chemotherapeutic drugs alone, so the scope of combined drug delivery has also been expanded to three aspects: drug-drug, drug-gene, and gene-gene. This review summarizes the recent advances of nanocarriers to co-delivery agents, including i) the characterization and preparation of nanocarriers, such as lipid-based nanocarriers, polymer nanocarriers, and inorganic delivery carriers; ii) the advantages and disadvantages of synergistic delivery approaches; iii) the effectual delivery cases that are applied in the synergistic delivery systems; and iv) future perspectives in the design of nanoparticle drug delivery systems to co-deliver therapeutic agents.
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页数:21
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