Efficient Synthesis of Two Chloramphenicol Derivatives as Antibacterial Agents

被引：0
作者：
Lauro, Figueroa-Valverde [1 ]
Francisco, Diaz-Cedillo [2 ]
Marcela, Rosas-Nexticapa [3 ]
Maria, Lopez-Ramos [1 ]
Magdalena, Alvarez-Ramirez [3 ]
Virginia, Mateu-Armad Maria [3 ]
Tomas, Lopez Gutierrez [1 ]
机构：
[1] Univ Autonomous Campeche, Fac Chem Biol Sci, Lab Pharmacochem, Av Agustin Melgar S-N, Campeche 24039, Camp, Mexico
[2] Inst Politecn Nacl, Escuela Nacl Ciencias Biol, Prol Carpio & Plan Ayala S-N, Mexico City 11340, DF, Mexico
[3] Univ Veracruzana, Fac Nutr, Unidad Bosque, Med & Odontol S-N, Xalapa 91010, Veracruz, Mexico
来源：
BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY | 2023年 / 13卷 / 03期
关键词：
synthesis; chloramphenicol; derivatives; Gram-positive; Gram-negative; ALKYL ACETAMIDE MOIETY; STEREOSELECTIVE-SYNTHESIS; C-9; IMINOETHER; BEARING; BINDING; RESISTANCE; SOLVATION; ANALOGS;
D O I：
10.33263/BRIAC133.227
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Several protocols have been used to prepare some chloramphenicol analogs using different reagents, which can be expensive and difficult to handle. The aim of this investigation was to synthesize six chloramphenicol analogs (compounds 2 to 7) using some chemical strategies to evaluate their biological activity against Staphylococcus aureus, Streptococcus pneumoniae, Escherichia coli, and Klebsiella pneumoniae with the minimum inhibitory concentration method. The results indicate that protocols used to synthesize chloramphenicol derivatives do not require special conditions such as different pH and higher temperatures to give a good yielding. Besides, only compounds 4 and 6 decreased the bacterial growth of either Gram-positive or Gram-negative bacteria. However, the biological activity of compound 4 was higher compared with both chloramphenicol and compound 6.
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页数：13
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