The Study of Core-Shell Cobalt Ferrite-Barium Titanate Magnetoelectric Nanoparticles in Targeting and Optimized Drug Delivery: An Overview

This review provides a comprehensive understanding of magnetoelectric (ME) nanocomposite, cobalt ferrite-barium titanate (CFO-BTO) as a potential candidate for targeting specific cells. The synthesized core-shell material uses strain-mediated coupling between magnetostrictive and piezoelectric material. CFO-BTO has the competitive advantage of a high ME coefficient and is biocompatible. The shape and size play a pivotal role in passive drug delivery due to the enhanced permeability and retention effect at tumor sites. Surfactants can also enhance drug absorption and influence the interaction with nanoparticle composite. A comparison between external magnetic field-frequency parameters to navigate the ME nanoparticle and trigger release of the drug at site is also reviewed. Coating the nanoparticles with a layer of surfactant can reduce the threshold external magnetic field for navigation and triggering of drug particle release, making the prospect viable for clinical studies.