Effects of Cinnamon (Cinnamomum zeylanicum) Extract on Adipocyte Differentiation in 3T3-L1 Cells and Lipid Accumulation in Mice Fed a High-Fat Diet

被引:5
|
作者
Oh, Joohee [1 ]
Ahn, SongHee [1 ]
Zhou, Xiangqin [1 ]
Lim, Yu Jin [1 ]
Hong, Sookyeong [1 ]
Kim, Hyun-Sook [1 ]
机构
[1] Sookmyung Womens Univ, Coll Human Ecol, Dept Food & Nutr, Seoul 04310, South Korea
关键词
metabolic syndrome; cinnamon; anti-obesity; adipocytes; lipolysis; AMP-activated kinase (AMPK); ACTIVATED PROTEIN-KINASE; ACID OXIDATION; CEYLON CINNAMON; METABOLISM; AMPK; ADIPONECTIN; OBESITY; LEPTIN; RISK;
D O I
10.3390/nu15245110
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Flavonoids and phenolic acid are two of the rich polyphenols found in cinnamon (Cinnamomum zeylanicum). The effects of cinnamon extract on the inhibition of adipocyte differentiation in 3T3-L1 fibroblast cells and prohibitory lipid accumulation in male mice fed a high-fat diet were examined. Upon treating 3T3-L1 cells with cinnamon for 3 days, the cinnamon inhibited lipid accumulation and increased gene expression levels, such as those of adiponectin and leptin. In in vivo experiments, mice were randomized into four groups after a one-week acclimation period, as follows: normal diet, normal diet + 1% cinnamon extract, high-fat diet, and high-fat diet + 1% cinnamon extract. After 14 weeks of supplementation, we found that cinnamon extract increased the expression of lipolysis-related proteins, such as AMPK, p-ACC, and CPT-1, and reduced the expression of lipid-synthesis-related proteins, such as SREBP-1c and FAS, in liver tissue. Our results show that cinnamon extract may exhibit anti-obesity effects via the inhibition of lipid synthesis and adipogenesis and the induction of lipolysis in both 3T3-L1 fibroblast cells and mice fed a high-fat diet. Accordingly, cinnamon extract may have potential anti-obesity effects.
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页数:18
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