Role of methyltransferase Set7 in obesity-related endothelial activation: functions beyond histone methylation

被引:0
|
作者
Ceinos, J. Sanchez [1 ,2 ]
Dottling, P. [1 ,2 ]
Jakobsson, M. E. [3 ]
Vegvari, A. [4 ]
Cosentino, F. [1 ,2 ]
机构
[1] Karolinska Univ Hosp, Dept Med, Cardiol Unit, Solna, Sweden
[2] Karolinska Inst, Stockholm, Sweden
[3] Lund Univ, Dept Immunotechnol, Fac Engn, Lund, Sweden
[4] Karolinska Inst, Dept Med Biochem & Biophys, Stockholm, Sweden
关键词
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页数:1
相关论文
共 50 条
  • [41] Epigenetic signatures induced by methyltransferase Set7 drive endothelial dysfunction and vascular inflammation in patients with type 2 diabetes
    Paneni, F.
    Costantino, S.
    Battista, R.
    Capretti, G.
    Castello, L.
    Chiandotto, S.
    Luscher, T. F.
    Volpe, M.
    Cosentino, F.
    EUROPEAN HEART JOURNAL, 2014, 35 : 1025 - 1025
  • [42] Homocysteine-targeting compounds as a new treatment strategy for diabetic wounds via inhibition of the histone methyltransferase SET7/9
    Guodong Li
    Dan Li
    Chun Wu
    Shengnan Li
    Feng Chen
    Peng Li
    Chung-Nga Ko
    Wanhe Wang
    Simon Ming-Yuen Lee
    Ligen Lin
    Dik-Lung Ma
    Chung-Hang Leung
    Experimental & Molecular Medicine, 2022, 54 : 988 - 998
  • [43] Obesity-related hypertension is mediated by sympathetic activation, but not endothelial nitric oxide deficiency
    Gamboa, A
    Shibao, C
    Diedrich, A
    Farley, G
    Paranjape, SY
    Biaggioni, I
    CIRCULATION, 2005, 112 (17) : U741 - U741
  • [44] Lead discovery, chemical optimization, and biological evaluation studies of novel histone methyltransferase SET7 small-molecule inhibitors
    Hou, Zeng
    Min, Wenjian
    Zhang, Rukang
    Niu, Ao
    Li, Yuanqing
    Cao, Liyuan
    Han, Jie
    Luo, Cheng
    Yang, Peng
    Ding, Hong
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 30 (09)
  • [45] Homocysteine-targeting compounds as a new treatment strategy for diabetic wounds via inhibition of the histone methyltransferase SET7/9
    Li, Guodong
    Li, Dan
    Wu, Chun
    Li, Shengnan
    Chen, Feng
    Li, Peng
    Ko, Chung-Nga
    Wang, Wanhe
    Lee, Simon Ming-Yuen
    Lin, Ligen
    Ma, Dik-Lung
    Leung, Chung-Hang
    EXPERIMENTAL AND MOLECULAR MEDICINE, 2022, 54 (07): : 988 - 998
  • [46] Discovery and Optimization of Novel, Selective Histone Methyltransferase SET7 Inhibitors by Pharmacophore- and Docking-Based Virtual Screening
    Meng, Fanwang
    Cheng, Sufang
    Ding, Hong
    Liu, Shien
    Liu, Yan
    Zhu, Kongkai
    Chen, Shijie
    Lu, Junyan
    Xie, Yiqian
    Li, Linjuan
    Liu, Rongfeng
    Shi, Zhe
    Zhou, Yu
    Liu, Yu-Chih
    Zheng, Mingyue
    Jiang, Hualiang
    Lu, Wencong
    Liu, Hong
    Luo, Cheng
    JOURNAL OF MEDICINAL CHEMISTRY, 2015, 58 (20) : 8166 - 8181
  • [47] Transcriptional Activity of the Islet β Cell Factor Pdx1 Is Augmented by Lysine Methylation Catalyzed by the Methyltransferase Set7/9
    Maganti, Aarthi V.
    Maier, Bernhard
    Tersey, Sarah A.
    Sampley, Megan L.
    Mosley, Amber L.
    Oezcan, Sabire
    Pachaiyappan, Boobalan
    Woster, Patrick M.
    Hunter, Chad S.
    Stein, Roland
    Mirmira, Raghavendra G.
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2015, 290 (15) : 9812 - 9822
  • [48] Role of protein arginine methyltransferase 1 in obesity-related metabolic disorders: Research progress and implications
    Xuan, Xiaolei
    Zhang, Yongjiao
    Song, Yufan
    Zhang, Bingyang
    Liu, Junjun
    Liu, Dong
    Lu, Sumei
    DIABETES OBESITY & METABOLISM, 2024, 26 (09): : 3491 - 3500
  • [49] SET7/9 Catalytic Mutants Reveal the Role of Active Site Water Molecules in Lysine Multiple Methylation
    Del Rizzo, Paul A.
    Couture, Jean-Francois
    Dirk, Lynnette M. A.
    Strunk, Bethany S.
    Roiko, Marijo S.
    Brunzelle, Joseph S.
    Houtz, Robert L.
    Trievel, Raymond C.
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 285 (41) : 31849 - 31858
  • [50] SET7 lysine methyltransferase mediates NLRP3 inflammasome priming and activation in atherosclerotic apolipoprotein E knockout mice
    Manea, A. Adrian
    Vlad, M. L.
    Lazar, A. G.
    Manea, S. A.
    EUROPEAN JOURNAL OF HEART FAILURE, 2024, 26 : 619 - 620