Bone health in children with recurrent and chronic pancreatitis: A multi-center cross sectional analysis

被引：1

作者：

Abu-El-Haija, Maisam ^{[1
,2
,21
]}

Hornung, Lindsey ^{[3
]}

Ellery, Kate ^{[4
]}

Fishman, Douglas S. ^{[5
,6
]}

Gonska, Tanja Y. ^{[7
]}

Gariepy, Cheryl ^{[8
]}

Lowe, Mark ^{[9
]}

Ode, Katie Larson ^{[10
,11
]}

Maqbool, Asim ^{[12
]}

Mascarenhas, Maria ^{[12
]}

Morinville, Veronique D. ^{[13
]}

Ooi, Chee Y. ^{[14
,15
]}

Perito, Emily R. ^{[16
]}

Schwarzenberg, Sarah Jane ^{[17
]}

Sellers, Zachary M. ^{[18
]}

Zemel, Babette S. ^{[12
]}

Yuan, Ying ^{[19
]}

Wang, Fuchenchu ^{[19
]}

Uc, Aliye ^{[10
,11
,20
]}

Kalkwarf, Heidi J. ^{[1
,2
]}

机构：

[1] Cincinnati Childrens Hosp Med Ctr, Div Gastroenterol Hepatol & Nutr, Cincinnati, OH 45229 USA

[2] Univ Cincinnati, Coll Med, Dept Pediat, Cincinnati, OH USA

[3] Cincinnati Childrens Hosp Med Ctr, Div Biostat & Epidemiol, Cincinnati, OH 45229 USA

[4] Univ Pittsburgh, Med Ctr, Div Pediat Gastroenterol Hepatol & Nutr, Pittsburgh, PA USA

[5] Baylor Coll Med, Div Pediat Gastroenterol Hepatol & Nutr, Houston, TX USA

[6] Texas Childrens Hosp, Houston, TX USA

[7] Hosp Sick Children, Toronto, ON, Canada

[8] Nationwide Childrens Hosp, Columbus, OH USA

[9] Washington Univ, Sch Med, Dept Pediat, St Louis, MO USA

[10] Univ Iowa, Dept Pediat, Iowa City, IA USA

[11] Univ Iowa, Fraternal Order Eagles Diabet Res Ctr, Iowa City, IA USA

[12] Childrens Hosp Philadelphia, Div Gastroenterol Hepatol & Nutr, Philadelphia, PA USA

[13] McGill Univ, Montreal Childrens Hosp, Montreal, PQ, Canada

[14] Univ New South Wales, Sch Clin Med, Discipline Paediat & Child Hlth, UNSW Med & Hlth, Sydney, Australia

[15] Sydney Childrens Hosp Randwick, Dept Gastroenterol, Sydney, Australia

[16] Univ Calif San Francisco, San Francisco, CA USA

[17] Univ Minnesota, Masonic Childrens Hosp, Minneapolis, MN USA

[18] Stanford Univ, Div Pediat Gastroenterol Hepatol & Nutr, Palo Alto, CA USA

[19] Univ Texas MD Anderson Canc Ctr, Dept Biostat, Houston, TX USA

[20] Univ Iowa, Radiat Oncol, Iowa City, IA USA

[21] Cincinnati Childrens Hosp Med Ctr, Pancreas Care Ctr, Div Gastroenterol Hepatol & Nutr, 3333Burnet Ave MLC 2010, Cincinnati, OH 45229 USA

来源：

PANCREATOLOGY | 2023年 / 23卷 / 07期

关键词：

Bone health; Children; Pancreatitis; SOLUBLE VITAMIN DEFICIENCIES; MINERAL DENSITY; LONGITUDINAL ASSESSMENT; ANTIOXIDANT STATUS; CYSTIC-FIBROSIS; CROHN-DISEASE; PREVALENCE; METABOLISM; CHILDHOOD; NUTRITION;

D O I：

10.1016/j.pan.2023.08.006

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background/objectives: Bone health of children with acute recurrent pancreatitis (ARP) and chronic pancreatitis (CP) is not well studied. Methods: This retrospective study was performed at three sites and included data from INSPPIRE-2.Results: Of the 87 children in the study: 46 had ARP (53%), 41 had CP (47%). Mean age was 13.6 +/- 3.9 years at last DXA scan. The prevalence of low height-for-age (Z-score <-2) (13%, 10/78) and low bone mineral density (BMD) adjusted for height (Z-score <-2) (6.4%, 5/78) were higher than a healthy reference sample (2.5%, p < 0.0001 and p 1/4 0.03, respectively).Conclusion: Children with ARP or CP have lower height and BMD than healthy peers. Attention to deficits in growth and bone mineral accrual in children with pancreatic disease is warranted.(c) 2023 IAP and EPC. Published by Elsevier B.V. All rights reserved.

引用

页码：755 / 760

页数：6

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