The challenge of identifying senescent cells

被引：22

作者：

Gil, Jesus ^{[1
,2
]}

机构：

[1] MRC Lab Med Sci LMS, London, England

[2] Imperial Coll London, Fac Med, Inst Clin Sci ICS, London, England

来源：

NATURE CELL BIOLOGY | 2023年 / 25卷 / 11期

关键词：

CELLULAR SENESCENCE;

D O I：

10.1038/s41556-023-01267-w

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Reliable ways to identify senescent cells represent a bottleneck for understanding the roles of senescence in physiology and disease. This Comment examines the challenges of identifying senescent cells, revises existing recommendations for how to best assess senescence and discusses how emerging technologies can address these issues.

引用

页码：1554 / 1556

页数：3

共 15 条

[1] Senolytic CAR T cells reverse senescence-associated pathologies [J].

Amor, Corina ;

Feucht, Judith ;

Leibold, Josef ;

Ho, Yu-Jui ;

Zhu, Changyu ;

Alonso-Curbelo, Direna ;

Mansilla-Soto, Jorge ;

Boyer, Jacob A. ;

Li, Xiang ;

Giavridis, Theodoros ;

Kulick, Amanda ;

Houlihan, Shauna ;

Peerschke, Ellinor ;

Friedman, Scott L. ;

Ponomarev, Vladimir ;

Piersigilli, Alessandra ;

Sadelain, Michel ;

Lowe, Scott W. .

NATURE, 2020, 583 (7814) :127-+

[2] Naturally occurring p16Ink4a-positive cells shorten healthy lifespan [J].

Baker, Darren J. ;

Childs, Bennett G. ;

Durik, Matej ;

Wijers, Melinde E. ;

Sieben, Cynthia J. ;

Zhong, Jian ;

Saltness, Rachel A. ;

Jeganathan, Karthik B. ;

Verzosa, Grace Casaclang ;

Pezeshki, Abdulmohammad ;

Khazaie, Khashayarsha ;

Miller, Jordan D. ;

van Deursen, Jan M. .

NATURE, 2016, 530 (7589) :184-+

[3] SENESCENCE Senescence in tumours: evidence from mice and humans [J].

Collado, Manuel ;

Serrano, Manuel .

NATURE REVIEWS CANCER, 2010, 10 (01) :51-57

[4] Pathological angiogenesis in retinopathy engages cellular senescence and is amenable to therapeutic elimination via BCL-xL inhibition [J].

Crespo-Garcia, Sergio ;

Tsuruda, Pamela R. ;

Dejda, Agnieszka ;

Ryan, Rathi D. ;

Fournier, Frederik ;

Chaney, Shawnta Y. ;

Pilon, Frederique ;

Dogan, Taner ;

Cagnone, Gael ;

Patel, Priyanka ;

Buscarlet, Manuel ;

Dasgupta, Sonali ;

Girouard, Gabrielle ;

Rao, Surabhi R. ;

Wilson, Ariel M. ;

O'Brien, Robert ;

Juneau, Rachel ;

Guber, Vera ;

Dubrac, Alexandre ;

Beausejour, Christian ;

Armstrong, Scott ;

Mallette, Frederick A. ;

Yohn, Christopher B. ;

Joyal, Jean-Sebastien ;

Marquess, Dan ;

Beltran, Pedro J. ;

Sapieha, Przemyslaw .

CELL METABOLISM, 2021, 33 (04) :818-+

[5] Cellular Senescence: Defining a Path Forward [J].

Gorgoulis, Vassilis ;

Adams, Peter D. ;

Alimonti, Andrea ;

Bennett, Dorothy C. ;

Bischof, Oliver ;

Bishop, Cleo ;

Campisi, Judith ;

Collado, Manuel ;

Evangelou, Konstantinos ;

Ferbeyre, Gerardo ;

Gil, Jesus ;

Hara, Eiji ;

Krizhanovsky, Valery ;

Jurk, Diana ;

Maier, Andrea B. ;

Narita, Masashi ;

Niedernhofer, Laura ;

Passos, Joao F. ;

Robbins, Paul D. ;

Schmitt, Clemens A. ;

Sedivy, John ;

Vougas, Konstantinos ;

von Zglinicki, Thomas ;

Zhou, Daohong ;

Serrano, Manuel ;

Demaria, Marco .

CELL, 2019, 179 (04) :813-827

[6] Defined p16High Senescent Cell Types Are Indispensable for Mouse Healthspan [J].

Grosse, Laurent ;

Wagner, Nicole ;

Emelyanov, Alexander ;

Molina, Clement ;

Lacas-Gervais, Sandra ;

Wagner, Kay-Dietrich ;

Bulavin, Dmitry, V .

CELL METABOLISM, 2020, 32 (01) :87-+

[7] Spatial mapping of cellular senescence: emerging challenges and opportunities [J].

Gurkar, Aditi U. ;

Gerencser, Akos A. ;

Mora, Ana L. ;

Nelson, Andrew C. ;

Zhang, Anru R. ;

Lagnado, Anthony B. ;

Enninful, Archibald ;

Benz, Christopher ;

Furman, David ;

Beaulieu, Delphine ;

Jurk, Diana ;

Thompson, Elizabeth L. ;

Wu, Fei ;

Rodriguez, Fernanda ;

Barthel, Grant ;

Chen, Hao ;

Phatnani, Hemali ;

Heckenbach, Indra ;

Chuang, Jeffrey H. ;

Horrell, Jeremy ;

Petrescu, Joana ;

Alder, Jonathan K. ;

Lee, Jun Hee ;

Niedernhofer, Laura J. ;

Kumar, Manoj ;

Konigshoff, Melanie ;

Bueno, Marta ;

Sokka, Miiko ;

Scheibye-Knudsen, Morten ;

Neretti, Nicola ;

Eickelberg, Oliver ;

Adams, Peter D. ;

Hu, Qianjiang ;

Zhu, Quan ;

Porritt, Rebecca A. ;

Dong, Runze ;

Peters, Samuel ;

Victorelli, Stella ;

Pengo, Thomas ;

Khaliullin, Timur ;

Suryadevara, Vidyani ;

Fu, Xiaonan ;

Bar-Joseph, Ziv ;

Ji, Zhicheng ;

Passos, Joao F. .

NATURE AGING, 2023, 3 (07) :776-790

[8] Unmasking Transcriptional Heterogeneity in Senescent Cells [J].

Hernandez-Segura, Alejandra ;

de Jong, Tristan V. ;

Melov, Simon ;

Guryev, Victor ;

Campisi, Judith ;

Demaria, Marco .

CURRENT BIOLOGY, 2017, 27 (17) :2652-+

[9] Senolytics prevent mt-DNA-induced inflammation and promote the survival of aged organs following transplantation [J].

Iske, Jasper ;

Seyda, Midas ;

Heinbokel, Timm ;

Maenosono, Ryoichi ;

Minami, Koichiro ;

Nian, Yeqi ;

Quante, Markus ;

Falk, Christine S. ;

Azuma, Haruhito ;

Martin, Friederike ;

Passos, Joao F. ;

Niemann, Claus U. ;

Tchkonia, Tamara ;

Kirkland, James L. ;

Elkhal, Abdallah ;

Tullius, Stefan G. .

NATURE COMMUNICATIONS, 2020, 11 (01)

[10] The Cancer SENESCopedia: A delineation of cancer cell senescence [J].

Jochems, Fleur ;

Thijssen, Bram ;

De Conti, Giulia ;

Jansen, Robin ;

Pogacar, Ziva ;

Groot, Kelvin ;

Wang, Liqin ;

Schepers, Arnout ;

Wang, Cun ;

Jin, Haojie ;

Beijersbergen, Roderick L. ;

de Oliveira, Rodrigo Leite ;

Wessels, Lodewyk F. A. ;

Bernards, Rene .

CELL REPORTS, 2021, 36 (04)

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