Re-defining 18F-DCFPyl prostate-specific membrane antigen positron emission tomography detected local recurrence from radical prostatectomy histopathology

被引:0
作者
Tissot, Sophie [1 ,3 ]
Wynn, Jessica [1 ]
Tran, Vy [1 ]
Farag, Matthew [1 ]
Wong, Lih-Ming [1 ]
Ng, Michael [2 ]
机构
[1] St Vincents Hosp Melbourne, Urol Dept, Fitzroy, Vic, Australia
[2] GenesisCare, St Vincents Hosp Melbourne, Fitzroy, Vic, Australia
[3] St Vincents Publ Hosp Melbourne, Dept Urol Surg, 41 Victoria Parade, Fitzroy, Vic 3065, Australia
关键词
Prostate-specific membrane antigen positron emission tomography (PSMA PET); prostate cancer; local recurrence; radical prostatectomy; histopathology; POSITIVE SURGICAL MARGIN; CANCER RECURRENCE; PSMA PET; PROGRESSION; PREDICTOR; PATTERNS; TUMOR; RISK;
D O I
10.1111/bju.16085
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
ObjectiveTo assess topographic concordance between the histopathological features of patients' radical prostatectomy (RP) specimens and the location of the prostate-specific membrane antigen positron emission tomography (PSMA PET) local recurrences, qualitatively and quantitatively.Patients and MethodsOur cohort was selected from the 100 men who received a F-18-DCFPyL PET scan in the IMPPORT trial (Australian New Zealand Clinical Trials Registry Number: ACTRN12618001530213), a prospective non-randomised study completed by GenesisCare Victoria. Eligibility included patients with a rising prostate-specific antigen (PSA) level (>0.2 ng/mL) after RP and PSMA PET detected local recurrence. Histopathological parameters collated included the location of tumour, extraprostatic extension (EPE), and positive margins. Criteria for the location and 'concordance' between histopathological features and local recurrences were pre-defined.ResultsA total of 24 patients were eligible; the median age was 71 years, the median PSA level was 0.37 ng/mL, and the time between RP and PSMA PET was 2.6 years. In all, 15 patients had recurrences within the vesicourethral anastomotic region and nine within the lateral surgical margins. There was 100% concordance in the left-right plane between tumour location and local recurrence, with 79% of these lesions concordant three-dimensionally; across craniocaudal, left-right, and anterior-posterior planes. In all, 10 of the 16 (63%) patients with EPE and five of the nine patients with positive margins had three-dimensional concordance between their pathology and their local recurrence. In quantitative assessment, 17 of the 24 patients, had local recurrences that correlated with the location of their original tumour in the craniocaudal plane.ConclusionLocal recurrence is highly concordant with the position of the tumour within the prostate. Predicting the location of local recurrence using the location of the EPE and positive margins is less helpful. Further investigation into this field, could impact surgical technique and salvage radiotherapy clinical target volume.
引用
收藏
页码:411 / 419
页数:9
相关论文
共 21 条
  • [1] Revisiting Prostate Cancer Recurrence with PSMA PET: Atlas of Typical and Atypical Patterns of Spread
    Barbosa, Felipe G.
    Queiroz, Marcelo A.
    Nunes, Rafael F.
    Viana, Publio C. C.
    Marin, Jose Flavio G.
    Cerri, Giovanni G.
    Buchpiguel, Carlos A.
    [J]. RADIOGRAPHICS, 2019, 39 (01) : 186 - 212
  • [2] Defining Prostatic Vascular Pedicle Recurrence and the Anatomy of Local Recurrence of Prostate Cancer on Prostate-specific Membrane Antigen Positron Emission Tomography/Computed Tomography
    Dundee, Philip
    Furrer, Marc A.
    Corcoran, Niall M.
    Peters, Justin
    Pan, Henry
    Ballok, Zita
    Ryan, Andrew
    Guerrieri, Mario
    Costello, Anthony J.
    [J]. EUROPEAN UROLOGY OPEN SCIENCE, 2022, 41 : 116 - 122
  • [3] The positive surgical margin after radical prostatectomy - Why do we still not really know what it means?
    Graefen, Markus
    [J]. EUROPEAN UROLOGY, 2006, 50 (02) : 199 - 201
  • [4] Mapping of Local Recurrences After Radical Prostatectomy Using 68-Gallium-Prostate- Specific Membrane Antigen Positron Emission Tomography/Computed Tomography : Implications for Postprostatectomy Radiation Therapy Clinical Target Volumes
    Horsley, Patrick J.
    Koo, Chung Mo
    Eade, Thomas
    Hsiao, Edward
    Emmett, Louise
    Brown, Chris
    Kneebone, Andrew
    Hruby, George
    [J]. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2023, 115 (01): : 106 - 117
  • [5] POSSIBLE MECHANISM FOR SEEDING OF TUMOR DURING RADICAL PROSTATECTOMY
    KASSABIAN, VS
    BOTTLES, K
    WEAVER, R
    WILLIAMS, RD
    PAULSON, DF
    SCARDINO, PT
    [J]. JOURNAL OF UROLOGY, 1993, 150 (04) : 1169 - 1171
  • [6] Patterns of disease detection using [18F]DCFPyL PET/CT imaging in patients with detectable PSA post prostatectomy being considered for salvage radiotherapy: a prospective trial
    Koschel, Samantha
    Taubman, Kim
    Sutherland, Thomas
    Yap, Kelvin
    Chao, Michael
    Guerrieri, Mario
    Benson, Angela
    Starmans, Michelle
    Byrne, Graeme
    Ong, Grace
    Macleod, Craig
    Foo, Marcus
    Wong, Lih Ming
    Gyomber, Dennis
    Ng, Michael
    [J]. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2021, 48 (11) : 3712 - 3722
  • [8] FROGG high-risk prostate cancer workshop: Patterns of practice and literature review. Part II post-radical prostatectomy
    Lehman, Margot
    Sidhom, Mark
    Kneebone, Andrew B.
    Hayden, Amy J.
    Martin, Jarad M.
    Christie, David
    Skala, Marketa
    Tai, Keen-Hun
    [J]. JOURNAL OF MEDICAL IMAGING AND RADIATION ONCOLOGY, 2014, 58 (03) : 392 - 400
  • [9] Tumor Seeding after Robot-Assisted Radical Prostatectomy: Literature Review and Experience from a Single Institution
    Motterle, Giovanni
    Ahmed, Mohamed E.
    Andrews, Jack R.
    Moschini, Marco
    Kwon, Eugene D.
    Karnes, R. Jeffrey
    [J]. JOURNAL OF UROLOGY, 2020, 203 (06) : 1141 - 1146
  • [10] EAU-EANM-ESTRO-ESUR-SIOG Guidelines on Prostate Cancer-2020 Update. Part 1: Screening, Diagnosis, and Local Treatment with Curative Intent
    Mottet, Nicolas
    van den Bergh, Roderick C. N.
    Briers, Erik
    Van den Broeck, Thomas
    Cumberbatch, Marcus G.
    De Santis, Maria
    Fanti, Stefano
    Fossati, Nicola
    Gandaglia, Giorgio
    Gillessen, Silke
    Grivas, Nikos
    Grummet, Jeremy
    Henry, Ann M.
    van der Kwast, Theodorus H.
    Lam, Thomas B.
    Lardas, Michael
    Liew, Matthew
    Mason, Malcolm D.
    Moris, Lisa
    Oprea-Lager, Daniela E.
    van der Poel, Henk G.
    Rouviere, Olivier
    Schoots, Ivo G.
    Tilki, Derya
    Wiegel, Thomas
    Willemse, Peter-Paul M.
    Cornford, Philip
    [J]. EUROPEAN UROLOGY, 2021, 79 (02) : 243 - 262