Long COVID: pathophysiological factors and abnormalities of coagulation

被引：89

作者：

Turner, Simone ^{[1
]}

Khan, M. Asad ^{[2
]}

Putrino, David ^{[3
]}

Woodcock, Ashley ^{[4
,5
]}

Kell, Douglas B. ^{[1
,6
,7
]}

Pretorius, Etheresia ^{[1
,6
]}

机构：

[1] Stellenbosch Univ, Fac Sci, Dept Physiol Sci, Private Bag X1, ZA-7602 Matieland, South Africa

[2] Manchester Univ Hosp, North West Lung Ctr, Manchester M23 9LT, England

[3] Icahn Sch Med Mt Sinai, Dept Rehabil & Human Performance, New York, NY 10029 USA

[4] Univ Manchester, Oxford Rd, Manchester M13 9PL, England

[5] Manchester Acad Hlth Sci Ctr, CityLabs, Manchester M13 9NQ, England

[6] Univ Liverpool, Inst Syst Mol & Integrat Biol, Fac Hlth & Life Sci, Dept Biochem & Syst Biol, Crown St, Liverpool L69 7ZB, England

[7] Tech Univ Denmark, Novo Nord Fdn Ctr Biosustainabil, Bldg 220, DK-2800 Lyngby, Denmark

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2023年 / 34卷 / 06期

基金：

新加坡国家研究基金会; 英国医学研究理事会;

关键词：

ISCHEMIA-REPERFUSION INJURY; RHEUMATOID-ARTHRITIS; TISSUE FACTOR; ORTHOSTATIC INTOLERANCE; SYSTEMIC INFLAMMATION; ACTIVATION; INFECTION; BLOOD; ANTIBODIES; RECEPTORS;

D O I：

10.1016/j.tem.2023.03.002

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Acute COVID-19 infection is followed by prolonged symptoms in approximately one in ten cases: known as Long COVID. The disease affects similar to 65 million individ-uals worldwide. Many pathophysiological processes appear to underlie Long COVID, including viral factors (persistence, reactivation, and bacteriophagic action of SARS CoV-2); host factors (chronic inflammation, metabolic and endocrine dys-regulation, immune dysregulation, and autoimmunity); and downstream impacts (tissue damage from the initial infection, tissue hypoxia, host dysbiosis, and autonomic nervous system dysfunction). These mechanisms culminate in the long-term persistence of the disorder characterized by a thrombotic endothelialitis, endothelial inflammation, hyperactivated platelets, and fibrinaloid microclots. These abnormalities of blood vessels and coagulation affect every organ system and represent a unifying pathway for the various symptoms of Long COVID.

引用

页码：321 / 344

页数：24

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