Neutrophil elastase: From mechanisms to therapeutic potential

被引：74

作者：

Zeng, Weilin ^{[1
]}

Song, Yingqiu ^{[1
]}

Wang, Runze ^{[1
]}

He, Rong ^{[2
]}

Wang, Tianlu ^{[1
]}

机构：

[1] China Med Univ, Liaoning Canc Hosp & Inst, Canc Hosp, Dept Radiotherapy, Shenyang 110000, Peoples R China

[2] China Med Univ, Liaoning Canc Hosp & Inst, Canc Hosp, Dept Surg, Shenyang 110000, Peoples R China

来源：

JOURNAL OF PHARMACEUTICAL ANALYSIS | 2023年 / 13卷 / 04期

关键词：

Neutrophil elastase; Sivelestat; COVID-19; Pathophysiological mechanisms; Therapeutic potential; EXTRACELLULAR TRAPS PROMOTE; CIRCULATING TUMOR-CELLS; ACUTE LUNG INJURY; KERATINOCYTE PROLIFERATION; IN-VITRO; CANCER; SIVELESTAT; INHIBITOR; INFLAMMATION; GROWTH;

D O I：

10.1016/j.jpha.2022.12.003

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Neutrophil elastase (NE), a major protease in the primary granules of neutrophils, is involved in microbicidal activity. NE is an important factor promoting inflammation, has bactericidal effects, and shortens the inflammatory process. NE also regulates tumor growth by promoting metastasis and tumor microenvironment remodeling. However, NE plays a role in killing tumors under certain conditions and promotes other diseases such as pulmonary ventilation dysfunction. Additionally, it plays a complex role in various physiological processes and mediates several diseases. Sivelestat, a specific NE inhibitor, has strong potential for clinical application, particularly in the treatment of coronavirus disease 2019 (COVID-19). This review discusses the pathophysiological processes associated with NE and the potential clinical applications of sivelestat.(c) 2023 The Authors. Published by Elsevier B.V. on behalf of Xi'an Jiaotong University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

引用

页码：355 / 366

页数：12

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