A reactive oxygen species-responsive covalent organic framework for tumor combination therapy

被引：12
作者：
Li, Wen-Yan [1 ]
Kan, Jing-Lan [1 ]
Wan, Jing-Jing [1 ]
Li, Yan-An [1 ]
Song, Tian [1 ]
Wang, Bo [1 ]
Guan, Qun [1 ]
Zhou, Le-Le [1 ]
Dong, Yu-Bin [1 ]
机构：
[1] Shandong Normal Univ, Collaborat Innovat Ctr Functionalized Probes Chem, Coll Chem Chem Engn & Mat Sci, Key Lab Mol & Nano Probes,Minist Educ, Jinan 250014, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2023年 / 59卷 / 36期
关键词：
COPPER; INHIBITION;
D O I：
10.1039/d3cc01136d
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Herein, we report the first reactive oxygen species (ROS)-responsive dithioketal-linked covalent organic framework (COF) for synergetic chemotherapy and photodynamic therapy (PDT) of cancer. The singlet oxygen (O-1(2))-responsive COF dissociation and DC_AC50 drug release complement and reinforce each other to allow an efficient combination of PDT and chemotherapy.
引用
收藏
页码：5423 / 5426
页数：4
相关论文
共 23 条
[1]  
[Anonymous], 2018, ACC SOFTW
[2]   Single-cell tracking demonstrates copper chaperone Atox1 to be required for breast cancer cell migration [J].
Blockhuys, Stephanie ;
Zhang, Xiaolu ;
Wittung-Stafshede, Pernilla .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2020, 117 (04) :2014-2019
[3]   Porous, crystalline, covalent organic frameworks [J].
Côté, AP ;
Benin, AI ;
Ockwig, NW ;
O'Keeffe, M ;
Matzger, AJ ;
Yaghi, OM .
SCIENCE, 2005, 310 (5751) :1166-1170
[4]   Targeting copper in cancer therapy: 'Copper That Cancer' [J].
Denoyer, Delphine ;
Masaldan, Shashank ;
La Fontaine, Sharon ;
Cater, Michael A. .
METALLOMICS, 2015, 7 (11) :1459-1476
[5]   Rationally Designed 2-in-1 Nanoparticles Can Overcome Adaptive Resistance in Cancer [J].
Goldman, Aaron ;
Kulkarni, Ashish ;
Kohandel, Mohammad ;
Pandey, Prithvi ;
Rao, Poornima ;
Natarajan, Siva Kumar ;
Sabbisetti, Venkata ;
Sengupta, Shiladitya .
ACS NANO, 2016, 10 (06) :5823-5834
[6]   Metalated covalent organic frameworks: from synthetic strategies to diverse applications [J].
Guan, Qun ;
Zhou, Le-Le ;
Dong, Yu-Bin .
CHEMICAL SOCIETY REVIEWS, 2022, 51 (15) :6307-+
[7]   Covalent Organic Frameworks (COFs) for Cancer Therapeutics [J].
Guan, Qun ;
Zhou, Le-Le ;
Li, Wen-Yan ;
Li, Yan-An ;
Dong, Yu-Bin .
CHEMISTRY-A EUROPEAN JOURNAL, 2020, 26 (25) :5583-5591
[8]   Nanoscale Covalent Organic Framework for Combinatorial Antitumor Photodynamic and Photothermal Therapy [J].
Guan, Qun ;
Zhou, Le-Le ;
Li, Yan-An ;
Li, Wen-Yan ;
Wang, Shumei ;
Song, Chun ;
Dong, Yu-Bin .
ACS NANO, 2019, 13 (11) :13304-13316
[9]   Copper levels in patients with hematological malignancies [J].
Kaiafa, Georgia D. ;
Saouli, Zoi ;
Diamantidis, Michael D. ;
Kontoninas, Zisis ;
Voulgaridou, Virginia ;
Raptaki, Maria ;
Arampatzi, Stergiani ;
Chatzidimitriou, Maria ;
Perifanis, Vasilios .
EUROPEAN JOURNAL OF INTERNAL MEDICINE, 2012, 23 (08) :738-741
[10]   Synthesis of Metal-Free Chiral Covalent Organic Framework for Visible-Light-Mediated Enantioselective Photooxidation in Water [J].
Kan, Xuan ;
Wang, Jian-Cheng ;
Chen, Zhi ;
Du, Jia-Qi ;
Kan, Jing-Lan ;
Li, Wen-Yan ;
Dong, Yu-Bin .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2022, 144 (15) :6681-6686
123