The Heritability of Subjective Cognitive Complaints in Older Australian Twins

被引：1
作者：
Selwood, Amanda E. [1 ]
Catts, Vibeke S. [1 ]
Numbers, Katya [1 ]
Lee, Teresa [1 ]
Thalamuthu, Anbupalam [1 ]
Wright, Margaret J. [2 ]
Sachdev, Perminder S. [1 ]
机构：
[1] Univ New South Wales, Ctr Hlth Brain Ageing, Discipline Psychiat & Mental Hlth, Sydney, NSW, Australia
[2] Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia
来源：
JOURNAL OF ALZHEIMERS DISEASE | 2023年 / 92卷 / 03期
基金：
英国医学研究理事会; 澳大利亚研究理事会; 澳大利亚国家健康与医学研究理事会;
关键词：
Affect; Alzheimer's disease; cognitive aging; depression; human genetics; memory disorders; neuroticism; personality; twin study; MEMORY COMPLAINTS; ALZHEIMERS-DISEASE; DANISH TWINS; DEPRESSION SYMPTOMATOLOGY; STRUCTURAL EQUATION; SYDNEY MEMORY; PERSONALITY; DECLINE; IMPAIRMENT; DEMENTIA;
D O I：
10.3233/JAD-221008
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Background: Subjective cognitive complaints (SCCs) may be a precursor to mild cognitive impairment (MCI) and dementia. Objective: This study aimed to examine the heritability of SCCs, correlations between SCCs and memory ability, and the influence of personality and mood on these relationships. Methods: Participants were 306 twin pairs. The heritability of SCCs and the genetic correlations between SCCs and memory performance, personality, and mood scores were determined using structural equation modelling. Results: SCCs were low to moderately heritable. Memory performance, personality and mood were genetically, environmentally, and phenotypically correlated with SCCs in bivariate analysis. However, in multivariate analysis, only mood and memory performance had significant correlations with SCCs. Mood appeared to be related to SCCs by an environmental correlation, whereas memory performance was related to SCCs by a genetic correlation. The link between personality and SCCs was mediated by mood. SCCs had a significant amount of both genetic and environmental variances not explained by memory performance, personality, or mood. Conclusion: Our results suggest that SCCs are influenced both by a person's mood and their memory performance, and that these determinants are not mutually exclusive. While SCCs had genetic overlap with memory performance and environmental association with mood, much of the genetic and environmental components that comprised SCCs were specific to SCCs, though these specific factors are yet to be determined.
引用
收藏
页码：1015 / 1026
页数：12
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