Immunomodulatory properties of mesenchymal stem cells/dental stem cells and their therapeutic applications

被引：110

作者：

Li, Peishan ^{[1
]}

Ou, Qianmin ^{[2
]}

Shi, Songtao ^{[2
]}

Shao, Changshun ^{[1
]}

机构：

[1] Soochow Univ, Affiliated Hosp 1, Inst Translat Med, State Key Lab Radiat Med & Protect, Suzhou, Peoples R China

[2] Sun Yat Sen Univ, Hosp Stomatol, South China Ctr Craniofacial Stem Cell Res, Guangdong Prov Key Lab Stomatol, Guangzhou, Peoples R China

来源：

CELLULAR & MOLECULAR IMMUNOLOGY | 2023年 / 20卷 / 06期

基金：

中国国家自然科学基金; 国家重点研发计划;

关键词：

Mesenchymal stem cells; Dental stem cells; Immunoregulation; Inflammation; ARYL-HYDROCARBON RECEPTOR; PERIODONTAL-LIGAMENT; T-CELLS; MEDIATED IMMUNOSUPPRESSION; EXTRACELLULAR VESICLE; M2; MACROPHAGES; BONE; GROWTH; MECHANISMS; ORIGIN;

D O I：

10.1038/s41423-023-00998-y

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Mesenchymal stem/stromal cells (MSCs) are widely distributed in the body and play essential roles in tissue regeneration and homeostasis. MSCs can be isolated from discarded tissues, expanded in vitro and used as therapeutics for autoimmune diseases and other chronic disorders. MSCs promote tissue regeneration and homeostasis by primarily acting on immune cells. At least six different types of MSCs have been isolated from postnatal dental tissues and have remarkable immunomodulatory properties. Dental stem cells (DSCs) have been demonstrated to have therapeutic effects on several systemic inflammatory diseases. Conversely, MSCs derived from nondental tissues such as the umbilical cord exhibit great benefits in the management of periodontitis in preclinical studies. Here, we discuss the main therapeutic uses of MSCs/DSCs, their mechanisms, extrinsic inflammatory cues and the intrinsic metabolic circuitries that govern the immunomodulatory functions of MSCs/DSCs. Increased understanding of the mechanisms underpinning the immunomodulatory functions of MSCs/DSCs is expected to aid in the development of more potent and precise MSC/DSC-based therapeutics.

引用

页码：558 / 569

页数：12

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