A Cyclobutanol Ring-Expansion Approach to Oxygenated Carbazoles: Total Synthesis of Glycoborine, Carbazomycin A and Carbazomycin B

被引：7
|
作者：
Natho, Philipp [1 ]
Allen, Lewis A. T. [1 ]
Parsons, Philip J. [1 ]
机构：
[1] Imperial Coll London, Dept Chem, London W12 0BZ, England
来源：
SYNLETT | 2023年 / 34卷 / 08期
基金：
英国工程与自然科学研究理事会;
关键词：
total synthesis; ring expansion; cyclization; antifungal agents; rearrangement; ALKALOIDS CARBAZOMYCIN; ORGANIC-SYNTHESIS; AMINATION; IDENTIFICATION; ANTIBIOTICS; COMPLEXES; ROOTS; ROUTE;
D O I：
10.1055/s-0042-1751411
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The transition-metal-free total syntheses of the oxygenated carbazole natural products glycoborine, carbazomycin A and carbazomycin B are reported. The key step involves an NBS-mediated cyclobutanol ring expansion to 4-tetralones for the preparation of the tricyclic carbazole core.
引用
收藏
页码：937 / 942
页数：6
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