Synthesis of α-CF3 Amides via Palladium-Catalyzed Carbonylation of 2-Bromo-3,3,3-trifluoropropene

被引：6

作者：

Wen, Xiao Rui ^{[1
]}

Zhu, Wen Qing ^{[1
]}

Zhang, Cai Lin ^{[1
]}

Li, Hong ^{[1
]}

Zhang, Jin ^{[1
]}

Yang, Min Ge ^{[1
]}

Kou, Yong Li ^{[2
]}

Liu, Yu Xia ^{[3
]}

Li, Yang ^{[1
]}

机构：

[1] Xian Polytech Univ, Sch Environm & Chem Engn, Xian 710048, Peoples R China

[2] Shaanxi Coal Chem Ind Technol Res Inst Co Ltd, Xian 710065, Peoples R China

[3] Northwest Univ, Coll Food Sci & Technol, Shaanxi Nat Carbohydrate Resource Engn Res Ctr, Xian 710127, Peoples R China

来源：

ACS OMEGA | 2023年

基金：

中国国家自然科学基金;

关键词：

MANNICH-TYPE REACTION; BETA-LACTAMS; ASYMMETRIC FLUORINATION; AMINO-ACIDS; C(SP(3))-H; TRIFLUOROMETHYLATION; CYCLOADDITION; AMIDATION; ALKENES;

D O I：

10.1021/acsomega.2c08206

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Amide compounds are important organic com-pounds, which play an important role in biomedical chemistry, materials science, life science, and other fields. The synthesis of alpha- CF3 amides, especially compounds containing 3-(trifluoromethyl)-1,3,4,5-tetrahydro-2H-benzo[b][1,4]diazepine-2-one, has long been a challenge due to the tensile properties and instability of the rings. Here, we report an example of palladium-catalyzed carbonylation of CF3-containing olefin to form alpha-CF3 acrylamide. By controlling the ligands, we can get different amide compounds as products. This method has good substrate adaptability and functional group tolerance.

引用

页码：7128 / 7134

页数：7

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