Serum uric acid/serum creatinine ratio as a predictor of cardiovascular events. Detection of prognostic cardiovascular cut-off values

被引：50

作者：

Casiglia, Edoardo ^{[1
]}

Tikhonoff, Valerie ^{[2
]}

Virdis, Agostino ^{[3
]}

Grassi, Guido ^{[4
]}

Angeli, Fabio ^{[5
]}

Barbagallo, Carlo M. ^{[6
]}

Bombelli, Michele ^{[4
]}

Cicero, Arrigo F. G. ^{[7
]}

Cirillo, Massimo ^{[8
]}

Cirillo, Pietro ^{[9
]}

Dell'Oro, Raffaella ^{[4
]}

D'elia, Lanfranco ^{[10
]}

Desideri, Giovambattista ^{[11
]}

Ferri, Claudio ^{[11
]}

Galletti, Ferruccio ^{[10
]}

Gesualdo, Loreto ^{[9
]}

Giannattasio, Cristina ^{[12
,13
]}

Iaccarino, Guido ^{[14
]}

Lippa, Luciano ^{[15
]}

Mallamaci, Francesca ^{[16
]}

Masi, Stefano ^{[3
]}

Maloberti, Alessandro ^{[12
,13
]}

Masulli, Maria ^{[10
]}

Mazza, Alberto ^{[17
]}

Mengozzi, Alessandro ^{[3
]}

Muiesan, Maria Lorenza ^{[18
]}

Nazzaro, Pietro ^{[19
]}

Palatini, Paolo ^{[1
]}

Parati, Gianfranco ^{[20
,21
]}

Pontremoli, Roberto ^{[22
,23
]}

Quarti-Trevano, Fosca ^{[4
]}

Rattazzi, Marcello ^{[2
,24
]}

Reboldi, Gianpaolo ^{[25
]}

Rivasi, Giulia ^{[26
,27
]}

Salvetti, Massimo ^{[18
]}

Tocci, Giuliano ^{[28
]}

Ungar, Andrea ^{[26
,27
]}

Verdecchia, Paolo ^{[29
]}

Viazzi, Francesca ^{[22
,23
]}

Volpe, Massimo ^{[28
]}

Borghi, Claudio ^{[7
]}

机构：

[1] Univ Padua, Dept Med, Studium Patavinum, Padua, Italy

[2] Univ Padua, Dept Med, Padua, Italy

[3] Univ Pisa, Dept Clin & Expt Med, Pisa, Italy

[4] Univ Milano Bicocca, Dept Med & Surg, Clin Med, Monza, Italy

[5] Univ Insubria, Dept Med & Surg, Varese, Italy

[6] Univ Palermo, Biomed Dept Internal Med & Specialist, Palermo, Italy

[7] Alma Mater Studiorum Univ Bologna, Dept Med & Surg Sci, Bologna, Italy

[8] Federico II Univ Naples, Dept Publ Hlth, Naples, Italy

[9] Aldo Moro Univ Bari, Dept Emergency & Organ Transplantat, Nephrol Dialysis & Transplantat Unit, Bari, Italy

[10] Federico II Univ Naples, Med Sch, Dept Clin Med & Surg, Naples, Italy

[11] Univ Aquila, Dept Life Hlth & Environm Sci, Laquila, Italy

[12] Osped Niguarda Ca Granda, A De Gasperis Dept, Cardiol 4, Milan, Italy

[13] Milano Bicocca Univ, Sch Med & Surg, Milan, Italy

[14] Federico II Univ Naples, Dept Adv Biomed Sci, Naples, Italy

[15] Italian Soc Gen Med SIMG, Laquila, Italy

[16] CNR IFC, Reggio Cal Unit, Clin Epidemiol Renal Dis & Hypertens, Reggio Di Calabria, Italy

[17] AULSS 5 Polesana, Dept Internal Med, Santa Maria Misericordia Gen Hosp, Rovigo, Italy

[18] Univ Brescia, Dept Clin & Expt Sci, Brescia, Italy

[19] Univ Bari, Med Sch, Dept Med Basic Sci Neurosci & Sense Organs, Bari, Italy

[20] S Luca Hosp, Ist Auxol Italiano, Milan, Italy

[21] Univ Milano Bicocca, Milan, Italy

[22] Univ Genoa, Dept Internal Med, Genoa, Italy

[23] Policlin San Martino, Genoa, Italy

[24] Ca Foncello Univ Hosp, Med Interna 1, Treviso, Italy

[25] Univ Perugia, Dept Med & Surg Sci, Perugia, Italy

[26] Careggi Hosp, Dept Geriatr & Intens Care Med, Florence, Italy

[27] Univ Florence, Florence, Italy

[28] Univ Rome Sapienza, Hypertens Unit, St Andrea Hosp, Dept Clin & Mol Med,Fac Med & Psychol,Div Cardiol, Rome, Italy

[29] Hosp S Maria Misericordia, Perugia, Italy

来源：

JOURNAL OF HYPERTENSION | 2023年 / 41卷 / 01期

关键词：

cardiovascular; creatinine; cut-off; epidemiology; uric acid; ACID RIGHT; MORTALITY; RISK; DISEASE; ASSOCIATION;

D O I：

10.1097/HJH.0000000000003319

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Objective:In the frame of the Uric Acid Right for Heart Health (URRAH) study, a nationwide multicenter study involving adult participants recruited on a regional community basis from all the territory of Italy under the patronage of the Working Group on Uric Acid and Cardiovascular Risk of the Italian Society of Hypertension, we searched for the cut-off values of the ratio between serum uric acid (SUA) and serum creatinine (sCr) able to predict cardiovascular (CV) events.Methods:Among 20 724 participants followed-up for 126 +/- 64 months, after detecting cut-off by the receiver operating characteristic curves, we calculated by Cox models adjusted for confounders having CV events as dependent variable the hazard ratio (HR) of SUA/sCr > cut-off. We also verified if the role of cut-off varied with increasing SUA/sCr.Results:A plausible prognostic cut-off of SUA/sCr was found and was the same in the whole database, in men and in women (>5.35). The HR of SUA/sCr > cut-off was 1.159 (95% confidence interval [CI] 1.092-1.131, P < 0.03) in all, 1.161 (95% CI 1.021-1.335, P < 0.02) in men, and 1.444 (95% CI 1.012-1.113, P < 0.03) in women. In increasing quintiles of SUA/sCr the cut-offs were >3.08, >4.87, >5.35, >6.22 and >7.58, respectively. The HRs significantly increased from the 3rd to the 5th quintile (1.21, 95% CI 1.032-1.467, P = 0.018; 1.294, 95% CI 1.101-1.521, P = 0.002; and 1.642, 95% CI 1.405-1.919, P < 0.0001; respectively), that is, over 5.35, whereas the 2nd quintile was not significantly different from the 1st (reference).Conclusion:Having SUA/sCr >5.35 is an independent CV risk indicator both in men and women. The cut-off is dynamic and significantly increases with increasing SUA/sCr.

引用

页码：180 / 186

页数：7

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