Targeted Drug Delivery Systems for Eliminating Intracellular Bacteria

被引：23

作者：

Feng, Wenli ^{[1
,2
]}

Chitto, Marco ^{[2
]}

Moriarty, Thomas Fintan ^{[2
]}

Li, Guofeng ^{[1
]}

Wang, Xing ^{[1
]}

机构：

[1] Beijing Univ Chem Technol, State Key Lab Organ Inorgan Composites, Beijing Lab Biomed Mat, Beijing 100029, Peoples R China

[2] AO Res Inst Davos, CH-7270 Davos, Switzerland

来源：

MACROMOLECULAR BIOSCIENCE | 2023年 / 23卷 / 01期

基金：

中国国家自然科学基金;

关键词：

active targeting; cellular internalization; drug delivery system; intracellular bacterial infection; stimuli-responsive; ACID-BASED HYDROGELS; CHITOSAN NANOPARTICLES; ANTIBACTERIAL ACTIVITY; DUAL PH; ANTIBIOTICS; SALMONELLA; INFECTIONS; NANOCARRIERS; MACROPHAGES; CLEARANCE;

D O I：

10.1002/mabi.202200311

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The intracellular survival of pathogenic bacteria requires a range of survival strategies and virulence factors. These infections are a significant clinical challenge, wherein treatment frequently fails because of poor antibiotic penetration, stability, and retention in host cells. Drug delivery systems (DDSs) are promising tools to overcome these shortcomings and enhance the efficacy of antibiotic therapy. In this review, the classification and the mechanisms of intracellular bacterial persistence are elaborated. Furthermore, the systematic design strategies applied to DDSs to eliminate intracellular bacteria are also described, and the strategies used for internalization, intracellular activation, bacterial targeting, and immune enhancement are highlighted. Finally, this overview provides guidance for constructing functionalized DDSs to effectively eliminate intracellular bacteria.

引用

页数：19

共 172 条

[31] Phosphatases and kinases delivered to the host cell by bacterial pathogens [J].

DeVinney, R ;

Steele-Mortimer, O ;

Finlay, BB .

TRENDS IN MICROBIOLOGY, 2000, 8 (01) :29-33

[32] Targeting Intracellular Pathogenic Bacteria Through N-Terminal Modification of Cationic Amphiphilic Polyproline Helices [J].

Dietsche, Thomas A. ;

Eldesouky, Hassan E. ;

Zeiders, Samantha M. ;

Seleem, Mohamed N. ;

Chmielewski, Jean .

JOURNAL OF ORGANIC CHEMISTRY, 2020, 85 (11) :7468-7475

[33] Ferrous Iron Uptake Is Required for Salmonella to Persist within Vacuoles of Host Cells [J].

Dominguez-Acuna, Lorena ;

Garcia-del Portillo, Francisco .

INFECTION AND IMMUNITY, 2022, 90 (06)

[34] A macrophage-based screen identifies antibacterial compounds selective for intracellular Salmonella Typhimurium [J].

Ellis, Michael J. ;

Tsai, Caressa N. ;

Johnson, Jarrod W. ;

French, Shawn ;

Elhenawy, Wael ;

Porwollik, Steffen ;

Andrews-Polymenis, Helene ;

McClelland, Michael ;

Magolan, Jakob ;

Coombes, Brian K. ;

Brown, Eric D. .

NATURE COMMUNICATIONS, 2019, 10 (1)

[35] Multimetallic Microparticles Increase the Potency of Rifampicin against Intracellular Mycobacterium tuberculosis [J].

Ellis, Timothy ;

Chiappi, Michele ;

Garcia-Trenco, Andres ;

Al-Ejji, Maryam ;

Sarkar, Srijata ;

Georgiou, Theoni K. ;

Shaffer, Milo S. P. ;

Tetley, Teresa D. ;

Schwander, Stephan ;

Ryan, Mary P. ;

Porter, Alexandra E. .

ACS NANO, 2018, 12 (06) :5228-5240

[36] Antibacterial nanotruffles for treatment of intracellular bacterial infection [J].

Elnaggar, Marwa G. ;

Jiang, Kunyu ;

Eldesouky, Hassan E. ;

Pei, Yihua ;

Park, Jinho ;

Yuk, Simseok A. ;

Meng, Fanfei ;

Dieterly, Alexandra M. ;

Mohammad, Haroon T. ;

Hegazy, Youssef A. ;

Tawfeek, Hesham M. ;

Abdel-Rahman, Aly A. ;

Aboutaleb, Ahmed E. ;

Seleem, Mohamed N. ;

Yeo, Yoon .

BIOMATERIALS, 2020, 262 (262)

[37] Intracellular replication of Streptococcus pneumoniae inside splenic macrophages serves as a reservoir for septicaemia [J].

Ercoli, Giuseppe ;

Fernandes, Vitor E. ;

Chung, Wen Y. ;

Wanford, Joseph J. ;

Thomson, Sarah ;

Bayliss, Christopher D. ;

Straatman, Kornelis ;

Crocker, Paul R. ;

Dennison, Ashley ;

Martinez-Pomares, Luisa ;

Andrew, Peter W. ;

Moxon, E. Richard ;

Oggioni, Marco R. .

NATURE MICROBIOLOGY, 2018, 3 (05) :600-610

[38] Polymersomes Eradicating Intracellular Bacteria [J].

Fenaroli, Federico ;

Robertson, James D. ;

Scarpa, Edoardo ;

Gouveia, Virginia M. ;

Di Guglielmo, Claudia ;

De Pace, Cesare ;

Elks, Philip M. ;

Poma, Alessandro ;

Evangelopoulos, Dimitrios ;

Canseco, Julio Ortiz ;

Prajsnar, Tomasz K. ;

Marriott, Helen M. ;

Dockrell, David H. ;

Foster, Simon J. ;

McHugh, Timothy D. ;

Renshaw, Stephen A. ;

Samitier Marti, Josep ;

Battaglia, Giuseppe ;

Rizzello, Loris .

ACS NANO, 2020, 14 (07) :8287-8298

[39] Cascade-Targeting Poly(amino acid) Nanoparticles Eliminate Intracellular Bacteria via On-Site Antibiotic Delivery [J].

Feng, Wenli ;

Li, Guofeng ;

Kang, Xiaoxu ;

Wang, Ruibai ;

Liu, Fang ;

Zhao, Dongdong ;

Li, Haofei ;

Bu, Fanqiang ;

Yu, Yingjie ;

Moriarty, T. Fintan ;

Ren, Qun ;

Wang, Xing .

ADVANCED MATERIALS, 2022, 34 (12)

[40] Self-Assembled Nanosized Vehicles from Amino Acid-Based Amphiphilic Polymers with Pendent Carboxyl Groups for Efficient Drug Delivery [J].

Feng, Wenli ;

Huang, Zixuan ;

Kang, Xiaoxu ;

Zhao, Dongdong ;

Li, Haofei ;

Li, Guofeng ;

Xu, Jiangtao ;

Wang, Xing .

BIOMACROMOLECULES, 2021, 22 (11) :4871-4882

← 1 2 3 4 5 6 7 8 9 10 →