Giant cell tumor of bone-an update

被引：0

作者：

Tschavoll, Felix ^{[1
]}

Lutteri, Gianluca ^{[1
]}

Leinauer, Benedikt ^{[1
]}

Mellert, Kevin ^{[1
]}

Moeller, Peter ^{[1
]}

Barth, Thomas F. E. ^{[1
]}

机构：

[1] Univ Klinikum Ulm, Inst Pathol, Albert Einstein Allee 23, D-89081 Ulm, Germany

来源：

PATHOLOGIE | 2023年 / 44卷 / 03期

关键词：

Giant cell tumor of bone; Giant cells; H3F3A mutation; Epigenome; Methylation analysis; RECEPTOR ACTIVATOR; KAPPA-B; OSTEOPROTEGERIN; LIGAND; DIFFERENTIATION; SARCOMA; H3F3A;

D O I：

10.1007/s00292-023-01271-9

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

In the past few years, numerous new insights have been gained in the field of giant cell tumor of bone (GCTB). On the one hand, the detection of the highly characteristic histone mutation in the H3F3A gene in GCTB is becoming increasingly important in diagnostics in differentiating GCTB from other giant cell-rich lesions of bone as well as for defining rare variants of GCTB without osteoclastic giant cells. On the other hand, the effects of the H3F3A mutation were shown to have an impact on the epigenetic profile of tumor-driving stromal cells, providing new insights into tumorigenesis of GCTB.

引用

页码：215 / 219

页数：5

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