Bioactive Polyurethane-Poly(ethylene Glycol) Diacrylate Hydrogels for Applications in Tissue Engineering

被引：3
作者：
Yuan, Yixuan [1 ]
Tyson, Caleb [2 ]
Szyniec, Annika [1 ]
Agro, Samuel [1 ]
Tavakol, Tara N. [3 ]
Harmon, Alexander [2 ]
Lampkins, Dessarae [2 ]
Pearson, Lauran [2 ]
Dumas, Jerald E. [4 ]
Taite, Lakeshia J. [1 ]
机构：
[1] Univ Virginia, Dept Chem Engn, Charlottesville, VA 22903 USA
[2] Hampton Univ, Dept Chem Engn, Hampton, VA 23668 USA
[3] Univ Virginia, Dept Biomed Engn, Charlottesville, VA 22908 USA
[4] North Carolina Agr & Tech State Univ, Joint Sch Nanosci & Nanoengn, Greensboro, NC 27401 USA
来源：
GELS | 2024年 / 10卷 / 02期
基金：
美国国家科学基金会;
关键词：
polyurethane; poly(ethylene glycol) diacrylate; hydrogels; photocrosslinking; cell adhesion; tissue engineering; scaffolds; YIGSR-PEPTIDE; MATRIX; ENDOTHELIALIZATION; POLYURETHANES; PEG; IMMOBILIZATION; COATINGS;
D O I：
10.3390/gels10020108
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
Polyurethanes (PUs) are a highly adaptable class of biomaterials that are among some of the most researched materials for various biomedical applications. However, engineered tissue scaffolds composed of PU have not found their way into clinical application, mainly due to the difficulty of balancing the control of material properties with the desired cellular response. A simple method for the synthesis of tunable bioactive poly(ethylene glycol) diacrylate (PEGDA) hydrogels containing photocurable PU is described. These hydrogels may be modified with PEGylated peptides or proteins to impart variable biological functions, and the mechanical properties of the hydrogels can be tuned based on the ratios of PU and PEGDA. Studies with human cells revealed that PU-PEG blended hydrogels support cell adhesion and viability when cell adhesion peptides are crosslinked within the hydrogel matrix. These hydrogels represent a unique and highly tailorable system for synthesizing PU-based synthetic extracellular matrices for tissue engineering applications.
引用
收藏
页数：14
相关论文
共 75 条
  • [11] Translational Applications of Hydrogels
    Correa, Santiago
    Grosskopf, Abigail K.
    Hernandez, Hector Lopez
    Chan, Doreen
    Yu, Anthony C.
    Stapleton, Lyndsay M.
    Appel, Eric A.
    [J]. CHEMICAL REVIEWS, 2021, 121 (18) : 11385 - 11457
  • [12] Covalent immobilization of RGDS on hydrogel surfaces to direct cell alignment and migration
    DeLong, SA
    Gobin, AS
    West, JL
    [J]. JOURNAL OF CONTROLLED RELEASE, 2005, 109 (1-3) : 139 - 148
  • [13] Mechanically Tunable Curcumin Incorporated Polyurethane Hydrogels as Potential Biomaterials
    Divakaran, Anumon V.
    Azad, Lal B.
    Surwase, Sachin S.
    Torris, Arun A. T.
    Badiger, Manohar V.
    [J]. CHEMISTRY OF MATERIALS, 2016, 28 (07) : 2120 - 2130
  • [14] Porous poly(ethylene glycol)-polyurethane hydrogels as potential biomaterials
    Divakaran, Anumon V.
    Torris, Arun A. T.
    Lele, Ashish K.
    Badiger, Manohar V.
    [J]. POLYMER INTERNATIONAL, 2015, 64 (03) : 397 - 404
  • [15] Injectable reactive biocomposites for bone healing in critical-size rabbit calvarial defects
    Dumas, Jerald E.
    BrownBaer, Pamela B.
    Prieto, Edna M.
    Guda, Teja
    Hale, Robert G.
    Wenke, Joseph C.
    Guelcher, Scott A.
    [J]. BIOMEDICAL MATERIALS, 2012, 7 (02)
  • [16] Synthesis, characterization, and remodeling of weight-bearing allograft bone/polyurethane composites in the rabbit
    Dumas, Jerald E.
    Davis, Thomas
    Holt, Ginger E.
    Yoshii, Toshitaka
    Perrien, Daniel S.
    Nyman, Jeffry S.
    Boyce, Todd
    Guelcher, Scott A.
    [J]. ACTA BIOMATERIALIA, 2010, 6 (07) : 2394 - 2406
  • [17] Hydrogel properties and applications
    Fu, Jun
    Panhuis, Marc In Het
    [J]. JOURNAL OF MATERIALS CHEMISTRY B, 2019, 7 (10) : 1523 - 1525
  • [18] Research progress of UV-curable polyurethane acrylate-based hardening coatings
    Fu, Junchao
    Wang, Li
    Yu, Haojie
    Haroon, Muhammad
    Haq, Fazal
    Shi, Wenlei
    Wu, Bin
    Wang, Libo
    [J]. PROGRESS IN ORGANIC COATINGS, 2019, 131 : 82 - 99
  • [19] A Synthetic Matrix with Independently Tunable Biochemistry and Mechanical Properties to Study Epithelial Morphogenesis and EMT in a Lung Adenocarcinoma Model
    Gill, Bartley J.
    Gibbons, Don L.
    Roudsari, Laila C.
    Saik, Jennifer E.
    Rizvi, Zain H.
    Roybal, Jonathon D.
    Kurie, Jonathan M.
    West, Jennifer L.
    [J]. CANCER RESEARCH, 2012, 72 (22) : 6013 - 6023
  • [20] Cell migration through defined, synthetic extracellular matrix analogues
    Gobin, AS
    West, JL
    [J]. FASEB JOURNAL, 2002, 16 (03) : 751 - +
12345678