Synthesis and Antichlamydial Activity of Oleanolic Acid Aza-Derivatives

被引：1
|
作者：
Kazakova, O. B. [1 ]
Rubanik, L. V. [2 ]
Petrova, A. V. [1 ]
Smirnova, I. E. [1 ]
Terekhova, A. V. [1 ]
Baikova, I. P. [1 ]
机构：
[1] Russian Acad Sci, Ufa Inst Chem, Ufa Fed Res Ctr, 71 Prosp Oktyabrya, Ufa 450054, Russia
[2] Republican Res & Pract Ctr Epidemiol & Microbiol, 23 Filimonova St, Minsk 220114, BELARUS
来源：
CHEMISTRY OF NATURAL COMPOUNDS | 2024年 / 60卷 / 01期
基金：
俄罗斯基础研究基金会;
关键词：
oleanolic acid; synthesis; aza-derivatives; Chlamydia trachomatis; antichlamydial activity; URSOLIC ACID; ANTIBACTERIAL; CERAMIDE;
D O I：
10.1007/s10600-024-04260-3
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Modification of oleanolic acid synthesized new N-containing derivatives with amino- and azepano-fragments in rings A and C that were highly active against C. trachomatis with a chemotherapeutic index > 8.
引用
收藏
页码：84 / 91
页数：8
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