Association of High-Sensitivity C-Reactive Protein and Lipoprotein-Associated Phospholipase A2 with Metabolically Unhealthy Phenotype: A Cross Sectional Study

被引：1

作者：

Wang, Jiangang ^{[1
,2
]}

Yang, Saiqi ^{[1
,2
]}

Zhao, Linlin ^{[1
,2
]}

机构：

[1] Cent South Univ, Xiangya Hosp 3, Hlth Management Ctr, Changsha 410013, Hunan, Peoples R China

[2] Cent South Univ, Hlth Management Res Ctr, Changsha 410013, Hunan, Peoples R China

来源：

JOURNAL OF INFLAMMATION RESEARCH | 2024年 / 17卷

基金：

中国国家自然科学基金;

关键词：

hs-CRP; Lp-PLA2; metabolically unhealthy; obese; NORMAL-WEIGHT; OBESE; HEALTHY; A(2); INFLAMMATION; DISEASE; RISK; EXPRESSION; BIOMARKER; MASS;

D O I：

10.2147/JIR.S447681

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Objective: Whether the combination of high-sensitivity C-reactive protein (hs-CRP) and Lipoprotein-associated Phospholipase A2 (Lp-PLA2) was an independent risk factor for metabolic unhealthy is unknown. This study aimed to evaluate the association between combining hs-CRP and Lp-PLA2 and metabolic unhealthy.Methods: A total of 3198 participants who underwent routine health check-up examinations. The participants completed inflammation indicators (hs-CRP and Lp-PLA2) examination and physical assessments. Four phenotypes were determined according to obesity and metabolic health status. Meanwhile, the participants were divided into four groups according to the level of hs-CRP and Lp-PLA2. The cross-sectional association between hs-CRP, Lp-PLA2 and metabolic unhealthy was tested by logistic regression analysis. Results: About 30.48%, 17.35%, 17.32% and 34.83% had MHNO, MUNO, MHO, and MUO, respectively. The combination of the hs-CRP and Lp-PLA2 levels was significantly correlated with metabolic unhealthy in non-obese subjects. However, in obese subjects, only hs-CRP level was significantly correlated with metabolic unhealthy. Conclusion: The hs-CRP and Lp-PLA2 together were significantly associated with metabolic unhealthy in non-obese subjects. hsCRP level was significantly correlated with metabolic unhealthy in obese subjects.

引用

页码：81 / 90

页数：10

共 35 条

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