Correlation between angiotensin and acute kidney injury in patients with sepsis

被引：0
作者：
Du, C. -b. [1 ]
Zhang, Y. -x. [2 ]
Du, R. [3 ]
Li, D. -l. [3 ]
Zhao, Z. -t. [3 ]
Lu, P. [3 ]
Liu, Y. [3 ]
Yang, X. -f. [3 ]
机构：
[1] Hebei Med Univ, Dept Mental Hlth, Hosp 1, Shijiazhuang, Peoples R China
[2] Hebei Med Univ, Dept Ultrasound, Hosp 1, Shijiazhuang, Peoples R China
[3] Hebei Med Univ, Dept Crit Care Med, Hosp 1, Shijiazhuang, Peoples R China
来源：
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES | 2023年 / 27卷 / 22期
关键词：
Sepsis; Acute kidney injury; Angiotensin; Endothelial dysregulation; DEFINITIONS; SHOCK;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
OBJECTIVE: The aim of the study was to analyze the changes in angiotensin (Ang) levels in patients with sepsis complicated with acute kidney injury (AKI) and evaluate the relationship between Ang and AKI.PATIENTS AND METHODS: Prospective research methods were used in this study. A total of 66 sepsis patients admitted to the Intensive care Unit (ICU) of the First Hospital of Hebei Medical University from October 2020 to January 2021 were enrolled. According to the occurrence of AKI, patients were divided into the sepsis-associated AKI (SA-AKI) group and the non-AKI group. The levels of Ang-1 and Ang-2 were compared between the two groups. The relationship between Ang and glomerular filtration rate (GFR) in sepsis patients was studied by correlation analysis.RESULTS: Plasma Ang-1 in the SA-AKI group was significantly higher than that in the non-AKI group (0.39 +/- 1.05 ng/ml vs. 0.10 +/- 0.24 ng/ml, p=0.039). The Ang-2/Ang-1 in the SA-AKI group was lower than that in the non-AKI group with a significant difference (52.55 +/- 191.38 vs. 349.50 +/- 327.49, p=0.001). Correlation analysis indicated that Ang-1 was negatively correlated with GFR (r=-0.12, p=0.031), while Ang-2/Ang-1 was positively correlated with GFR (r=0.21, p<0.001). The Ang-2 was positively correlated with GFR (r=0.204, p<0.001) CONCLUSIONS: Plasma Ang-1 and Ang-2 levels are suggestive for assessing the risk of AKI in patients with sepsis.CONCLUSIONS: Plasma Ang-1 and Ang-2 levels are suggestive for assessing the risk of AKI in patients with sepsis.
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收藏
页码：11109 / 11114
页数：6
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