Survival and acute exacerbation for patients with idiopathic pulmonary fibrosis (IPF) or non-IPF idiopathic interstitial pneumonias: 5-year follow-up analysis of a prospective multi-institutional patient registry

被引：10

作者：

Tsubouchi, Kazuya ^{[1
]}

Hamada, Naoki ^{[2
]}

Tokunaga, Shoji ^{[3
]}

Ichiki, Katsuyuki ^{[4
]}

Takata, Shohei ^{[5
]}

Ishii, Hiroshi ^{[6
]}

Kitasato, Yasuhiko ^{[7
]}

Okamoto, Masaki ^{[8
]}

Kawakami, Satoru ^{[9
]}

Yatera, Kazuhiro ^{[10
]}

Kawasaki, Masayuki ^{[11
]}

Fujita, Masaki ^{[2
]}

Yoshida, Makoto ^{[12
]}

Maeyama, Takashige ^{[13
]}

Harada, Taishi ^{[14
]}

Wataya, Hiroshi ^{[15
]}

Torii, Ryo ^{[16
]}

Komori, Masashi ^{[17
]}

Mizuta, Yuichi ^{[18
]}

Tobino, Kazunori ^{[19
]}

Harada, Eiji ^{[20
]}

Yabuuchi, Hidetake ^{[21
]}

Nakanishi, Yoichi ^{[22
]}

Okamoto, Isamu ^{[1
]}

机构：

[1] Kyushu Univ, Grad Sch Med Sci, Dept Resp Med, Fukuoka, Japan

[2] Fukuoka Univ, Sch Med, Dept Resp Med, Fukuoka, Japan

[3] Kyushu Univ Hosp, Med Informat Ctr, Fukuoka, Japan

[4] Kirigaoka Tsuda Hosp, Kitakyushu, Japan

[5] Natl Hosp Org, Fukuoka Higashi Med Ctr, Dept Resp Dis, Fukuoka, Japan

[6] Fukuoka Univ, Chikushi Hosp, Dept Resp Med, Chikushino, Japan

[7] Japan Community Hlth Care Org Kurume Gen Hosp, Dept Resp Med, Kurume, Japan

[8] Kurume Univ, Sch Med, Dept Internal Med, Div Respirol Neurol & Rheumatol, Kurume, Japan

[9] Kyushu Rosai Hosp, Div Resp Med, Kitakyushu, Japan

[10] Univ Occupat & Environm Hlth Japan, Dept Resp Med, Kitakyushu, Japan

[11] Natl Hosp Org Omuta Natl Hosp, Dept Resp Med, Omuta, Japan

[12] Natl Hosp Org, Fukuoka Natl Hosp, Dept Resp Dis, Fukuoka, Japan

[13] Hamanomachi Hosp, Dept Resp Med, Fukuoka, Japan

[14] Japan Community Hlth Care Org Kyushu Hosp, Dept Resp Med, Kitakyushu, Japan

[15] Saiseikai Fukuoka Gen Hosp, Dept Resp Med, Fukuoka, Japan

[16] Univ Occupat & Environm Hlth, Wakamatsu Hosp, Dept Resp Med, Kitakyushu, Japan

[17] Steel Mem Yawata Hosp, Dept Resp Med, Kitakyushu, Japan

[18] St Marys Hosp, Dept Resp Med, Kurume, Japan

[19] Aso Iizuka Hosp, Div Resp Med, Iizuka, Japan

[20] Kitakyushu Municipal Med Ctr, Dept Resp Med, Kitakyushu, Japan

[21] Kyushu Univ, Grad Sch Med Sci, Dept Hlth Sci, Fukuoka, Japan

[22] Kitakyushu City Hosp Org, Kitakyushu, Japan

来源：

BMJ OPEN RESPIRATORY RESEARCH | 2023年 / 10卷 / 01期

关键词：

Clinical Epidemiology; Interstitial Fibrosis; CLASSIFICATION; DIAGNOSIS; UPDATE;

D O I：

10.1136/bmjresp-2023-001864

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

ObjectiveFew prospective cohort studies with relatively large numbers of patients with non-idiopathic pulmonary fibrosis (non-IPF) of idiopathic interstitial pneumonia (IIP) have been described. We aimed to assess disease progression and cause of death for patients with non-IPF IIPs or IPF under real-life conditions.MethodsData were analysed for a prospective multi-institutional cohort of 528 IIP patients enrolled in Japan between September 2013 and April 2016. Diagnosis of IPF versus non-IPF IIPs was based on central multidisciplinary discussion, and follow-up surveillance was performed for up to 5 years after patient registration. Survival and acute exacerbation (AE) were assessed.ResultsIPF was the most common diagnosis (58.0%), followed by unclassifiable IIPs (35.8%) and others (6.2%). The 5-year survival rate for non-IPF IIP and IPF groups was 72.8% and 53.7%, respectively, with chronic respiratory failure being the primary cause of death in both groups. AE was the second most common cause of death for both non-IPF IIP (24.1%) and IPF (23.5%) patients. The cumulative incidence of AE did not differ significantly between the two groups (p=0.36), with a 1-year incidence rate of 7.4% and 9.0% in non-IPF IIP and IPF patients, respectively. We found that 30.2% and 39.4% of non-IPF IIP and IPF patients, respectively, who experienced AE died within 3 months after an AE event, whereas 55.8% and 66.7% of such patients, respectively, died within 5 years after registration.ConclusionCloser monitoring of disease progression and palliative care interventions after AE are important for non-IPF IIP patients as well as for IPF patients.

引用

页数：11

共 1 条

[1] Burden of Idiopathic Pulmonary Fibrosis Progression: A 5-Year Longitudinal Follow-Up Study
Cottin, Vincent
Schmidt, Aurelie
Catella, Laura
Porte, Fanny
Fernandez-Montoya, Celine
Le Lay, Katell
Benard, Steve
PLOS ONE, 2017, 12 (01):

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