Paternal age and risk for selected birth defects in a large South American sample

被引：1

作者：

Gili, Juan A. ^{[1
,2
,3
]}

Rittler, Monica ^{[1
,2
,4
]}

Heisecke, Silvina ^{[5
]}

Campana, Hebe ^{[1
,2
,6
]}

Gimenez, Lucas ^{[1
,2
,7
]}

Santos, Maria Rita ^{[1
,2
,6
,8
]}

Ratowiecki, Julia ^{[1
,2
]}

Cosentino, Viviana ^{[1
,2
,9
]}

Camelo, Jorge Lopez ^{[1
,2
,7
]}

Poletta, Fernando A. ^{[1
,2
,7
,10
]}

机构：

[1] Consejo Nacl Invest Cient & Tecn CEMIC CONICET, Ctr Educ Med & Invest Clin, Lab Epidemiol Genet, Buenos Aires, Buenos Aires, Argentina

[2] Consejo Nacl Invest Cient & Tecn CEMIC CONICET, Ctr Educ Med & Invest Clin, Estudio Colaborat Latinoamer Malformac Congenitas, Buenos Aires, Buenos Aires, Argentina

[3] Univ Nacl Villa Maria, Inst Acad Pedag Ciencias Humanas, Cordoba, Argentina

[4] Hosp Materno Infantil Ramon Sarda, Buenos Aires, Argentina

[5] Consejo Nacl Invest Cient & Tecn CEM CONICET, Ctr Educ Med & Invest Clin, Direcc Invest, Buenos Aires, Buenos Aires, Argentina

[6] Comis Invest Cient CICpBA, Buenos Aires, Argentina

[7] Consejo Nacl Invest Cient & Tecn, Inst Nacl Genet Med Populac INAGEMP, CEMIC, Buenos Aires, Buenos Aires, Argentina

[8] UNLP, Inst Multidisciplinario Biol Celular IMBICE, CONICET, CICPBA, Buenos Aires, Argentina

[9] Hosp Interzonal Gen Agudos Luisa C Gandulfo, Buenos Aires, Argentina

[10] Hosp Univ CEM, Consejo Nacl Invest Cient & Tecn CEMIC CONICET, Ctr Educ Med Invest Clin, Galvan 4102, RA-1431 Buenos Aires, Argentina

来源：

BIRTH DEFECTS RESEARCH | 2023年 / 115卷 / 19期

关键词：

anal atresia; birth defect; esophageal atresia; maternal age; paternal age; preaxial polydactyly; PARENTAL AGE; CONGENITAL-MALFORMATIONS; ANOMALIES; HEALTH; ACHONDROPLASIA; ASSOCIATION; PREVALENCE; MUTATIONS; ECLAMC;

D O I：

10.1002/bdr2.2252

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

BackgroundThe relationship between maternal age (MA) and birth defects (BD) has been extensively studied while much less research, mostly with discordant results, has focused on the risk of paternal age (PA) for BD. Furthermore, no consensus has been reached on the best way to control the association of PA with MA.ObjectivesThe aim of the study was to evaluate the risk of PA increase, at 1-year intervals, for selected BD, especially controlling for the confounding effect of MA.MethodsThe sample comprised of 27,944 liveborns presenting 1 of 18 selected isolated BD. Conditional logistic regressions were applied to evaluate the risk of advanced PA and its yearly increase, adjusting by MA and other variables.ResultsOf the 18 analyzed BD, only the risk for preaxial polydactyly (PreP) showed a significant association with increasing PA, while advanced MA was of low risk. For esophageal and anal atresia, associations with both PA and MA increases were observed.ConclusionsResults support the hypothesis of advanced PA as a risk factor for PreP and helps clarify the so far unexplained nonrandom association between this defect and Down syndrome.

引用

页码：1866 / 1875

页数：10

共 60 条

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