Metal-free synthesis of selenoesters directly from carboxylic acids using bifunctional selenoureas under batch and continuous-flow conditions

被引：10

作者：

Mhate, Mouzma ^{[1
,2
]}

Mahanta, Chandra Sekhara ^{[1
,2
]}

Dhaked, Devendra K. ^{[3
]}

Ravichandiran, Velyutham ^{[1
,2
]}

Swain, Sharada Prasanna ^{[1
,2
]}

机构：

[1] Natl Inst Pharmaceut Educ & Res Kolkata, Dept Med Chem, 168 Maniktala Main Rd, Kolkata 700054, India

[2] Natl Inst Pharmaceut Educ & Res Kolkata, Ctr Marine Therapeut CMT, 168 Maniktala Main Rd, Kolkata 700054, India

[3] Natl Inst Pharmaceut Educ & Res Kolkata, Dept Pharmacoinformat, 168 Maniktala Main Rd, Kolkata 700054, India

来源：

CHEMICAL COMMUNICATIONS | 2023年 / 59卷 / 73期

关键词：

DIPHENYL DISELENIDE; TELLUROL ESTERS; ACYL CHLORIDES; ALKYL-HALIDES; ALDEHYDES; CLEAVAGE; THIOL; SE;

D O I：

10.1039/d3cc02872k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new metal-free method for the synthesis of selenoesters directly from carboxylic acids in a flow reactor is reported. The carboxylic acids, Michael acceptors, and bifunctional selenoureas (source of selenium and nucleophile, activator of carbonyl group) were reacted to obtain selenoesters (up to 70% yield). An evidence-backed plausible mechanism is also presented.

引用

页码：10920 / 10923

页数：5

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