Safety and Feasibility of Riociguat Therapy for the Treatment of Chronic Pulmonary Arterial Hypertension in Infancy

被引：9

作者：

Giesinger, Regan E. ^{[1
]}

Stanford, Amy H. ^{[1
]}

Thomas, Brady ^{[1
]}

Abman, Steven H. ^{[2
]}

McNamara, Patrick J. ^{[1
]}

机构：

[1] Univ Iowa, Dept Pediat, Iowa City, IA USA

[2] Univ Colorado, Dept Pediat, Denver, CO USA

来源：

JOURNAL OF PEDIATRICS | 2023年 / 255卷

关键词：

SOLUBLE GUANYLATE-CYCLASE; BRONCHOPULMONARY DYSPLASIA; ECHOCARDIOGRAPHY; SILDENAFIL; DISEASE;

D O I：

10.1016/j.jpeds.2022.11.026

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

The effects of riociguat, an oral-soluble guanylate-cyclase stimulator, were studied in 10 infants with chronic pulmonary arterial hypertension. Respiratory status (n = 8/10), right heart dilation (n = 7/10), function (n = 9/10), and chronic pulmonary arterial hypertension (n = 8/10) improved. Median decrement in systolic (12 [4, 14]), diastolic (14 [7, 20]), and mean arterial (14 [10, 17]) pressures were noted; no critical hypotension or hypoxemia occurred.

引用

页码：224 / +

页数：7

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