Emerging self-powered piezoelectric based nanobiomaterials as a platform for accelerated wound healing: recent advances and future perspectives

Spontaneous generation of native endogenous electric fields (EFs) after wounding is the hallmark of enhanced wound healing (WH). Focus has been given toward creation of smart technologies that provide an external EF. Piezoelectric based dressings when applied to wound sites can conveniently generate EF in response to body's natural movement and promote WH. In this perspective, piezoelectric nanobiomaterials are gaining significant attention due to their high surface energy and complex cell-material interactions. This review discusses role of EF in WH simultaneously exploring their development and use for skin regeneration. Important properties of these materials and future directions are also discussed.