Microwave-Assisted Synthesis of Methylenebis(phenyl-1H-1,2,3-triazol-5-yl-1,3-thiazolidinones) as Potential Anticancer Agents

被引：2

作者：

Srinivas, A. ^{[1
]}

Rajitha, S. R. ^{[2
]}

Suresh, P. D. ^{[3
]}

机构：

[1] Vaagdevi Coll Ramnagar, Res & Dev Div, Hanamkonda 506001, India

[2] Carrier Point Univ, Sch Sci, Kota 325003, India

[3] Vaagdevi Degree & PG Coll, Dept Zool, Hanamkonda 506001, India

来源：

RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2023年 / 93卷 / 05期

关键词：

hybrid heterocycles; microwave irradiation; click-reaction; thiazolidinones; triazoles; anticancer activity; MULTICOMPONENT REACTIONS; CHEMISTRY; 4-THIAZOLIDINONES; THIAZOLIDIN-4-ONES; DESIGN; ACID;

D O I：

10.1134/S1070363223050213

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of hybrid heterocycles was synthesized from methylenebis(thiazolidinone carboxylic acids) by treating with propargyl bromide and p-chlorophenyl azide under microwave irradiation at 65 & DEG;C by using glucose as catalyst. Anticancer activity of the prepared compounds was evaluated by in vitro screening technique against different cancer cell lines DU145, A549, HELA, MCF. Compounds with the 4-Cl, 4-NO2, 4-F, and 4-CH3 groups showed significant anticancer activity against all cell lines examined.

引用

页码：1201 / 1209

页数：9

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