Role of sirtuins in hepatocellular carcinoma progression and multidrug resistance: Mechanistical and pharmacological perspectives

被引：6
作者：
Ceballos, Maria Paula [1 ]
Quiroga, Ariel Dario [1 ,2 ,3 ]
Palma, Nicolas Francisco [1 ,2 ]
机构：
[1] Fac Ciencias Bioquim & Farmaceut, Inst Fisiol Expt IFISE, CONICET, UNR, Suipacha 570, RA-S2002LRL Rosario, Argentina
[2] Fac Ciencias Bioquim & Farmaceut, Area Morfol, UNR, Suipacha 570, RA-S2002LRL Rosario, Argentina
[3] Univ Abierta Interamer, Ctr Altos Estudios Ciencias Humanas & Salud CAECIH, Av Pellegrini 1618, RA-S2000BUG Rosario, Argentina
来源：
BIOCHEMICAL PHARMACOLOGY | 2023年 / 212卷
关键词：
Sirtuins; Hepatocellular carcinoma; Multidrug resistance; POTENTIAL THERAPEUTIC TARGET; SELF-RENEWAL; CELL-GROWTH; TUMOR-SUPPRESSOR; SIRT1; INHIBITOR; P-GLYCOPROTEIN; IN-VITRO; MITOCHONDRIAL DEACETYLASE; MESENCHYMAL TRANSITION; LIVER TUMORIGENESIS;
D O I：
10.1016/j.bcp.2023.115573
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Hepatocellular carcinoma (HCC) is the third most common cause of death from cancer worldwide. Therapeutic strategies are still challenging due to the high relapse rate after surgery and multidrug resistance (MDR). It is essential to better understand the mechanisms for HCC progression and MDR for the development of new therapeutic strategies. Mammalian sirtuins (SIRTs), a family of seven members, are related to tumor progression,
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页数：29
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