Role of sirtuins in hepatocellular carcinoma progression and multidrug resistance: Mechanistical and pharmacological perspectives

被引：6

作者：

Ceballos, Maria Paula ^{[1
]}

Quiroga, Ariel Dario ^{[1
,2
,3
]}

Palma, Nicolas Francisco ^{[1
,2
]}

机构：

[1] Fac Ciencias Bioquim & Farmaceut, Inst Fisiol Expt IFISE, CONICET, UNR, Suipacha 570, RA-S2002LRL Rosario, Argentina

[2] Fac Ciencias Bioquim & Farmaceut, Area Morfol, UNR, Suipacha 570, RA-S2002LRL Rosario, Argentina

[3] Univ Abierta Interamer, Ctr Altos Estudios Ciencias Humanas & Salud CAECIH, Av Pellegrini 1618, RA-S2000BUG Rosario, Argentina

来源：

BIOCHEMICAL PHARMACOLOGY | 2023年 / 212卷

关键词：

Sirtuins; Hepatocellular carcinoma; Multidrug resistance; POTENTIAL THERAPEUTIC TARGET; SELF-RENEWAL; CELL-GROWTH; TUMOR-SUPPRESSOR; SIRT1; INHIBITOR; P-GLYCOPROTEIN; IN-VITRO; MITOCHONDRIAL DEACETYLASE; MESENCHYMAL TRANSITION; LIVER TUMORIGENESIS;

D O I：

10.1016/j.bcp.2023.115573

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Hepatocellular carcinoma (HCC) is the third most common cause of death from cancer worldwide. Therapeutic strategies are still challenging due to the high relapse rate after surgery and multidrug resistance (MDR). It is essential to better understand the mechanisms for HCC progression and MDR for the development of new therapeutic strategies. Mammalian sirtuins (SIRTs), a family of seven members, are related to tumor progression,

引用

页数：29

共 268 条

[1] Virtual Screening in the Identification of Sirtuins' Activity Modulators [J].

Abbotto, Elena ;

Scarano, Naomi ;

Piacente, Francesco ;

Millo, Enrico ;

Cichero, Elena ;

Bruzzone, Santina .

MOLECULES, 2022, 27 (17)

[2] Molecular docking and mechanisms of fusaric acid induced mitochondrial sirtuin aberrations in glycolytically and oxidatively poised human hepatocellular carcinoma (HepG2) cells [J].

Abdul, Naeem Sheik ;

Nagiah, Savania ;

Anand, Krisnan ;

Chuturgoon, Anil A. .

TOXICON, 2020, 173 :48-56

[3] Fusaric acid induces mitochondrial stress in human hepatocellular carcinoma (HepG2) cells [J].

Abdul, Naeem Sheik ;

Nagiah, Savania ;

Chuturgoon, Anil A. .

TOXICON, 2016, 119 :336-344

[4] A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis [J].

Ahn, Bong-Hyun ;

Kim, Hyun-Seok ;

Song, Shiwei ;

Lee, In Hye ;

Liu, Jie ;

Vassilopoulos, Athanassios ;

Deng, Chu-Xia ;

Finkel, Toren .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (38) :14447-14452

[5] SIRT3 and cancer: Tumor promoter or suppressor? [J].

Alhazzazi, Turki Y. ;

Kamarajan, Pachiyappan ;

Verdin, Eric ;

Kapila, Yvonne L. .

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2011, 1816 (01) :80-88

[6] Pharmacogenetics of hepatocellular carcinoma and cholangiocarcinoma [J].

Alonso-Pena, Marta ;

Sanchez-Martin, Anabel ;

Sanchon-Sanchez, Paula ;

Soto-Muniz, Meraris ;

Espinosa-Escudero, Ricardo ;

Marin, Jose J. G. .

CANCER DRUG RESISTANCE, 2019, 2 (03) :680-709

[7] The Pleiotropic Function of Human Sirtuins as Modulators of Metabolic Pathways and Viral Infections [J].

Alqarni, Mohammed Hamed ;

Foudah, Ahmed Ibrahim ;

Muharram, Magdy Mohamed ;

Labrou, Nikolaos E. .

CELLS, 2021, 10 (02) :1-20

[8] Function of the SIRT3 mitochondrial deacetylase in cellular physiology, cancer, and neurodegenerative disease [J].

Ansari, Aneesa ;

Rahman, Md. Shahedur ;

Saha, Subbroto K. ;

Saikot, Forhad K. ;

Deep, Akash ;

Kim, Ki-Hyun .

AGING CELL, 2017, 16 (01) :4-16

[9] Overexpression of SLC25A51 promotes hepatocellular carcinoma progression by driving aerobic glycolysis through activation of SIRT5 [J].

Bai, Lu ;

Yang, Zhao-Xu ;

Ma, Peng-Fei ;

Liu, Jian-Shan ;

Wang, De-Sheng ;

Yu, Heng-Chao .

FREE RADICAL BIOLOGY AND MEDICINE, 2022, 182 :11-22

[10] SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation [J].

Barber, Matthew F. ;

Michishita-Kioi, Eriko ;

Xi, Yuanxin ;

Tasselli, Luisa ;

Kioi, Mitomu ;

Moqtaderi, Zarmik ;

Tennen, Ruth I. ;

Paredes, Silvana ;

Young, Nicolas L. ;

Chen, Kaifu ;

Struhl, Kevin ;

Garcia, Benjamin A. ;

Gozani, Or ;

Li, Wei ;

Chua, Katrin F. .

NATURE, 2012, 487 (7405) :114-+

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